【衡道丨干货】RET——非小细胞肺癌精准治疗的新靶点|RET|衡道
2020年12月3日 · RET（Rearranged during Transfection）原癌基因最早于1985年由 Takahashi等通过人类T细胞淋巴瘤DNA转染小鼠NIH-3T3细胞而发现并命名 [1]。 RET原癌基因定位于 …
RET 融合阳性晚期非小细胞肺癌治疗进展 - PubMed Central (PMC)
转染重排（rearranged during transfection, RET）融合阳性发生于0.7%-2%的非小细胞肺癌（non-small cell lung cancer, NSCLC）。 RET 基因与其他结构域之间的融合代表了NSCLC独特的生 …
Current concepts in RET-related genetics, signaling and ... - Cell …
The receptor tyrosine kinase RET is expressed in cell lineages derived from the neural crest and has a key role in regulating cell proliferation, migration, differentiation and survival during …
An integrative pan cancer analysis of RET aberrations and their ...
2022年8月17日 · RET (rearranged during transfection), encoding a tyrosine kinase receptor, is a novel therapeutic target for cancers. The aberrations of RET are commonly found in cancers.
Vepafestinib is a pharmacologically advanced RET-selective …
2023年9月21日 · We demonstrate that vepafestinib has best-in-class selectivity against RET, while exerting activity against commonly reported on-target resistance mutations (variants in …
RET receptor signaling: Function in development, metabolic …
The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are responsible for various human cancers and developmental disorders, including thyroid cancer, non-small …
RET signaling pathway and RET inhibitors in human cancer
2022年6月27日 · Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty years ago as a novel transforming gene. Since its discovery and …
RET gene - MedlinePlus
The RET gene provides instructions for producing a protein that is involved in signaling within cells. This protein appears to be essential for the normal development of several kinds of …
Novel Human-Derived RET Fusion NSCLC Cell Lines Have
We developed three novel RET fusion-positive (RET+) patient-derived cancer cell lines, CUTO22 [kinesin 5B (KIF5B)-RET fusion], CUTO32 (KIF5B-RET fusion), and CUTO42 (echinoderm …
RET Gene - GeneCards | RET Protein | RET Antibody
2024年12月25日 · RET (Ret Proto-Oncogene) is a Protein Coding gene. Diseases associated with RET include Hirschsprung Disease 1 and Multiple Endocrine Neoplasia, Type Iia. Among …