2024年12月25日 · RGS10 (Regulator Of G Protein Signaling 10) is a Protein Coding gene. Diseases associated with RGS10 include Schizophrenia and Osteopetrosis. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.

RGS10 is a key molecule that contributes to the inhibition of Galpha-dependent signaling during chemokine-activated alpha4beta1- and alphaLbeta2-dependent T cell adhesion. RGS10 and RGS4 proteins are both detected in postmortem prefrontal cortex.

RGS10 is the smallest protein of the D/R12 subfamily and selectively interacts with Gαi proteins. It is widely expressed in many cells and tissues, with the highest expression found in the brain and immune cells. RGS10 expression is transcriptionally regulated via epigenetic mechanisms.

2020年11月1日 · RGS10 is the smallest protein of the D/R12 subfamily and selectively interacts with Gαi proteins. It is widely expressed in many cells and tissues, with the highest expression found in the brain and immune cells. RGS10 expression is transcriptionally regulated via epigenetic mechanisms.

2015年1月1日 · Regulator of G protein signaling-10 (RGS10), a GTPase-activating protein (GAP) for Gα i3, Gα q, and Gα z, belongs to the D/R12 subfamily based on the homology within the RGS domain and is one of the smallest RGS proteins, outside the RGS box.

蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。 它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节器 10 属于该家族。 所有 RGS 蛋白都共享一个保守的 120 个氨基酸序列，称为 RGS 结构域。 这种蛋白质与两个相关 G 蛋白亚基 G-alphai3 和 G-alphaz 的活化形式特异性结合，但不能与结构和功能不同的 G-alpha 亚基相互作用。 G 蛋白 …

2013年9月25日 · Regulator of G-protein Signaling 10 (Rgs10) plays an important function in osteoclast differentiation. However, the role of Rgs10 in immune cells and inflammatory responses, which activate...

2018年1月1日 · The regulator of G protein signaling 10 (RGS10) protein is a regulatory molecule that belongs to a larger family of RGS proteins responsible for altering cellular signaling. Generally, RGS proteins are negative regulators of signal transduction pathways mediated by heterotrimeric G proteins.

RGS10 suppresses classical M1 activation through the downregulation of NF-κB activation and inflammatory cytokines release, and promotes markers of the alternatively activated M2 phenotype [101]. RGS10 also modulates NLRP3 and NLRC4 inflammasome activity in …

RGS10 has emerged as a key regulator of proinflammatory cytokine production in microglia, functioning as an important neuroprotective factor. Although RGS10 is normally expressed in microglia at high levels, expression is silenced in vitro following activation of TLR4 receptor.