2005年8月15日 · RhoGDI (Rho GDP-dissociation inhibitor) was identified as a down-regulator of Rho family GTPases typified by its ability to prevent nucleotide exchange and membrane association. Structural studies on GTPase-RhoGDI complexes, in combination with biochemical and cell biological results, have provided …

2024年2月19日 · Rho GTPases是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶 ，属于 Ras超家族 ，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等多种成员。

RHO protein GDP dissociation inhibitor of Rho proteins (rho GDI) regulates GDP/GTP exchange. The protein plays an important role in the activation of the oxygen superoxide-generating NADPH oxidase of phagocytes.

2005年7月1日 · Based largely on biochemical and in vitro evidence, GDP dissociation inhibitor (GDI) is proposed to regulate both the interactions of Rho GTPases with regulators and effector targets, as well as cytosol-to-membrane cycling. In resting cells, Rho GTPase–GDI complexes are cytosolic and non-interactive.

GDI mediates the release of RHO GTPases from the membrane, maintains them in an inactivated state, and safeguards them against degradation or nonspecific activation by RHOGEFs [25,29,30]. Different structural studies have revealed two sites of GDI and RHO GTPase interaction [ 70 , 71 , 72 , 73 , 74 ].

2011年7月22日 · RHO-specific guanine nucleotide dissociation inhibitors (RHOGDIs) are a family of proteins that have key roles in the regulation of the RHO GTPases. RHOGDIs function...

Rho-specific guanine nucleotide dissociation inhibitors (RhoGDIs) play a crucial role in the regulation of Rho family GTPases. They act as negative regulators that prevent the activation of Rho GTPases by forming complexes with the inactive GDP-bound state of GTPase.

The GDI proteins are key components of the regulatory machinery controlling both the timing and the localization of Rho GTPase activity. Recent structural work has provided significant insight into the mechanisms by which the GDI proteins control Rho-family signalling.

2000年2月4日 · The GDI acts as an important inhibitor of signaling through Rho family GTP-binding proteins, and the X-ray crystallographic structure of the Cdc42/GDI complex reported here reveals important atomic detail of this critical regulatory interaction.

RhoGDI (Rho GDP-dissociation inhibitor) was identified as a down-regulator of Rho family GTPases typified by its ability to prevent nucleotide exchange and membrane association. Structural studies on GTPase–RhoGDI complexes, in combination with ...