The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate …

2024年2月19日 · Rho GTPases 是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶，属于 Ras超家族，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等 …

RHO GTPases contain a highly conserved G domain, which is responsible for GDP/GTP binding and GTP hydrolysis. Switch I and switch II regions are the consensus binding sites for GEFs, …

2016年6月15日 · Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for …

2021年7月20日 · It seems that 20 canonical RHO GTPases are likely regulated by three GDIs, 85 GEFs, and 66 GAPs, and eventually interact with >70 downstream effectors. A recurring …

2012年12月1日 · Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP …

2002年12月12日 · These small, monomeric GTPases, which number over 60 in mammals, fall into five major groups: Ras, Rho, Rab, Arf and Ran. This review focuses specifically on Rho …

2024年1月3日 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and …

RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP …

2025年2月1日 · Once activated, Rho GTPases relocate to the plasma membrane (PM) or other intracellular compartments to selectively interact with downstream effectors. GTPase …