RhoGEF domain - Wikipedia
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are …
Systems analysis of RhoGEF and RhoGAP regulatory proteins …
2020年3月23日 · Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase …
The RhoGEF Trio: A Protein with a Wide Range of Functions in the ...
2021年9月21日 · The RhoGEF Trio contains two GEF domains that differentially activate the small GTPases such as Rac1/RhoG and RhoA. These small RhoGTPases are mainly involved …
The RhoGEF Trio: A Protein with a Wide Range of Functions in the ...
Many cellular processes are controlled by small GTPases, which can be activated by guanine nucleotide exchange factors (GEFs). The RhoGEF Trio contains two GEF domains that …
Interaction kinetics between p115-RhoGEF and Gα - Nature
2022年11月24日 · RhoGEFs (guanine nucleotide exchange factors for small GTPases of the Rho family) are known to be key players in the regulation of cell shape, cell differentiation and cell …
<br>RhoGEF 和 RhoGAP 调节蛋白的系统分析揭示了整合素粘附的 …
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Rho GTPases are central regulators of the cytoskeleton …
Regulation of RhoGEF proteins by G12/13-coupled receptors
RGS proteins for G 12/13 proteins are RhoGEFs, four of which are known to be regulated by G 12 -type proteins: p115-RhoGEF, PSD-95/Disc-large/ZO-1 homology (PDZ)-RhoGEF, leukemia …
Rho guanine nucleotide exchange factors: regulators of Rho …
2013年9月16日 · One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs). …
rho鸟嘌呤核苷酸交换因子家族及其在疾病发生中的作用 - 豆丁网
2016年4月26日 · RhoGTPase在调节细胞骨架形成、基因转录、nucleotideexchangefactor，GEF），能够催化GDP转. 细胞周期及膜泡运输中起着重要的作 …
Systematic analysis of RhoGEF/GAP localizations uncovers …
2023年2月13日 · To decipher the mechanisms of RhoGTPase spatiotemporal regulation during epithelial cell division, we generated a transgenic fluorescently tagged library for the 48 …