重要综述！细胞信号传导蛋白——Rho GTPases - 知乎
2024年2月19日 · Rho GTPases通过调节细胞骨架重塑、细胞迁移、细胞黏附、细胞极化和基因转录等过程参与细胞生物学的多个方面。 在这篇综述中，作者提出并讨论了Rho GTPases的自 …
Rho family of GTPases - Wikipedia
GEFs activate Rho proteins by catalyzing the exchange of GDP for GTP. GAPs control the ability of the GTPase to hydrolyze GTP to GDP, controlling the natural rate of movement from the …
The RHO Family GTPases: Mechanisms of Regulation and Signaling
Crystallographic studies of RHOGAP domains in complex with CDC42 bound to GppNHp, RHOA/CDC42 bound to GDP·AlF 4 [76,77,95] and RHOA bound to GDP·MgF 3 have …
RHOA蛋白在细胞骨架重组中的作用 - 百家号
RHOA蛋白是Rho家族小GTP酶中的一员，主要在调控细胞骨架重组、细胞迁移、极. 性形成、细胞分裂和信号传导等过程中发挥重要作用。 RHOA通过调节肌动蛋白和微. 管的重组，控制细胞 …
Patterning of the cell cortex by Rho GTPases - Nature
2024年1月3日 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and …
RHO GTPases: from new partners to complex immune syndromes
2021年2月5日 · Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering multiple immune functions. Through their interactions with a broad range of effectors …
RhoA GTPase和RhoA途径中各种转录因子的调节 ... - X-MOL
2018年1月30日 · RhoA GTPase在调节细胞骨架蛋白，细胞形态和迁移以及细胞中各种增殖和转录活性方面发挥多种功能。 RhoA活性受鸟嘌呤核苷酸交换因子（GEF），GTPase活化蛋 …
Regulation of RhoA GTPase and various transcription factors in the RhoA ...
RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular morphology, and migration along with various proliferation and transcriptional activity in cells. …
Regulating Rho GTPases and their regulators - Nature
2016年6月15日 · Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for …
Protocol for structural and biochemical analyses of RhoA GTPase
2021年6月18日 · We first describe the procedure for the expression and purification of RhoA in both GDP-bound and GTP analog-bound forms. We then describe the procedure of …