2006年4月9日 · We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical...

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses.

黑色素瘤分化相关基因5（Melanoma differentiation-associated gene 5，简称MDA-5）也被称为IFIH1基因或Helicard基因。该基因位于染色体2q24.3上，是一个早期干扰素β反应性基因。 MDA-5在抗病毒免疫反应中起到关…

MAVS(mitochondrial antiviral signaling protein)是一种位于线粒体外膜上的信号蛋白，含有CARD结构域，在结合MDA-5/RIG-I后能招募TRAF家族蛋白，最后激活NFκB和IRF信号通路。

rig-i偏爱结合5’三磷酸基团的双链dsrna，以及较短的dsrna，而mda5则对较长的dsrna有更高的亲和力。大量的研究表明rig-i负责识别仙台病毒(sev)、水疱性口炎病毒(vsv)、新城疫病毒(ndv)和流感病毒，而mda5则主要识别小rna病毒。还有一些rna病毒可被二者共同识别。

MDA-5 (melanoma-differentiation-associated gene 5) and RIG-I (retinoic-acid-inducible protein 1) are cytoplasmic RNA helicases that belong to the RIG-I-like receptors (RLRs) family and are critical for host antiviral responses [1].

2008年2月1日 · This study demonstrated that RIG-I and MDA5 recognize different RNA viruses and RNA structures by generating mice deficient in RIG-I and MDA5. RIG-I −/− and MDA5 −/− cells showed defective type I IFN production to viruses recognized by them.

Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production.

RIG-I and MDA5 are the principal sensors of viral dsRNA in the cytoplasm. The interferon-dependent inflammatory response triggered by RLR ligand binding is one of the first and most important lines of defense against infection. RIG-I and MDA5 recognize distinct and complementary sets of viral dsRNA ligands.

2013年9月5日 · Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5′-triphosphate (5′-ppp) RNA and mediate IFN production.