Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene. [5] [6] [7] This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases.

2024年12月25日 · RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with RIPK2 include Crohn's Disease and Leprosy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

Receptor-interacting protein kinase 2 (RIPK2) is a downstream signaling molecule of nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2) and plays a cru-cial role in regulating NOD-mediated inflammatory responses. The NOD-RIPK2 pathway is associ-ated with various inflammatory diseases.

2023年11月5日 · RIPK2 is an upstream regulator of stress-induced caspase-1 activation, which is essential for neuronal death induced by overexpression of RIPK2 [29]. Therefore, RIPK2 is considered as a novel therapeutic target of ALS and HD.

2022年2月3日 · Here we show receptor-interacting protein kinase 2 (RIPK2) is a clinically actionable target for inhibiting PC metastasis. RIPK2 is amplified/gained in ~65% of lethal metastatic...

2023年10月19日 · 受体相互作用丝氨酸/苏氨酸蛋白激酶 2 (ripk2) 是一种下游信号分子，对于激活多种先天免疫受体（包括 nod 样受体（nod1 和 nod2））至关重要。 NOD1/2 对病原体相关分子模式蛋白的识别导致它们与 RIPK2 相互作用，RIPK2 通过激活 NF-κB 和 MAPK 途径等诱导促炎细胞 …

2023年11月5日 · The present study reviews the molecule structure and biological functions of RIPK2, and its correlation between human diseases. In addition, we focus on the structure-activity relationship of small molecule inhibitors of RIPK2 and their therapeutic potential in …

2024年2月8日 · Our data showed that receptor-interacting protein kinase 2 (RIPK2) is a crucial driver of immune evasion of cytotoxic T-cell killing and that genetic or pharmacologic targeting of RIPK2 sensitizes PDAC to anti-programmed cell death protein 1 (anti-PD-1) immunotherapy, leading to prolonged survival or complete regression.

该研究应用体内CRISPR筛选确定RIPK2是免疫逃避的关键驱动因素，并通过 新格元 GEXSCOPE® 单细胞转录组测序 (scRNA-Seq)技术 发现CD8+T细胞是PDAC肿瘤免疫微环境 (TME)中受RIPK2缺陷影响最严重的免疫细胞类型，随后发现用基因敲除或小分子抑制剂靶向RIPK2可增强PDAC对 免疫检查点阻断 (ICB)治疗敏感性。 研究结果揭示了 受体相互作用蛋白激酶2 是胰脏癌的免疫治疗靶点，为PDAC的新型联合疗法 (RIPK2抑制联合抗PD-1免疫疗法)提供了 …

2023年9月30日 · Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1, NF-κB, and MAPK pathway activation.