2024年4月29日 · Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting protein kinase (RIPK) family with serine/threonine protein kinase...

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans. [5] [6] [7] [8] The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal domain unique from other RIP family members.

rip3(ripk3)是丝氨酸/苏氨酸蛋白激酶，可激活坏死和凋亡这两种平行的细胞死亡形式。 激活的ripk3形成一个诱导坏死的复合物，并介导mlkl的磷酸化，促进mlkl定位到质膜并执行程序性坏死，其特征是钙内流和质膜损伤。

2024年12月25日 · RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with RIPK3 include Herpes Simplex and Caspase 8 Deficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and RIPK1-mediated regulated necrosis.

2022年10月12日 · In the initial studies highlighting its discovery, receptor-interacting protein kinase-3 (RIPK3, also referred to as RIP3) was proposed to be a regulator of apoptosis downstream...

RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as TNFα-tumor necrosis factor α) and infection-induced necroptosis, a programmed necrosis.

RIPK3是受体相互作用蛋白激酶（receptor interacting protein kinase）家族成员之一，与RIPK1形成坏死小体，激活MLKL，诱发细胞程序性坏死。 RIPK3作为细胞程序性坏死的关键调控分子，在炎症和肿瘤中都发挥重要作用 【3,4】。 其可以促进炎症性肠病（IBD）肠道粘膜的修复，抑制炎症相关性结直肠癌的形成 【5】。 RIPK3与肠癌分期负相关，是结肠癌的重要预后因子。 然而，RIPK3如何调控结直肠癌免疫微环境仍是待解之谜。 该论文以自发炎症相关性结直肠癌为实 …

受体相互作用蛋白激酶3（receptor interacting protein kinase 3,RIPK3）是受体相互作用的丝氨酸/苏氨酸蛋白激酶家族成员,可通过RIPK1-RIPK3-混合谱系激酶结构域样蛋白（mixed lineage kinase domain like...

凋亡和坏死是IRI（心脏缺血再灌注损伤）背景下PCD（程序性细胞死亡）的主要类型，研究表明，坏死实际上是再灌注损伤死亡的主要原因。大约50%的细胞死亡可以通过Ripk3基因的缺失被阻断，一些研究认为，Ripk3坏死作…

北大等团队发现细胞外 RIPK3 与 PCI 术后 MACE 正相关，其作为 DAMP 经 RAGE/CaMKII 通路加重心脏 I/R 损伤，为相关防治提供新靶点与视角。 心肌缺血是由于冠状动脉斑块破裂或侵蚀等导致的冠状动脉血流受阻的病生理过程，是引起心肌损伤的最主要的原因之一。 治疗心肌缺血的最佳方法是通过经皮冠状动脉介入治疗 (percutaneous coronary intervention, PCI)、冠状动脉旁路移植术 (coronary artery bypass grafting, CABG)或溶栓治疗等，及时、充分地恢复冠状动脉血供 ( …