Because the mechanism of mitochondrial RIRR highlights the central role of mitochondria-formed ROS, we discuss all of the known ROS-producing sites (shown in vitro) and their relevance to the mitochondrial ROS production in vivo.

典型例子是一个线粒体产生的活性氧（ros）会诱导其他线粒体释放ros（rirr）。 线粒体还可以通过摄取和释放Ca2+传播凋亡信号波。 线粒体动力学 ——融合和裂变

2014年7月1日 · 这种线粒体 ros 形成和释放的再生循环被称为 ros 诱导的 ros 释放 (rirr)。 简短的，可逆的 mPTP 开放相关 ROS 释放显然构成了一种适应性看家功能，通过从线粒体中及时释放积累的潜在毒性水平的 ROS（和 Ca(2+)）。

2018年7月1日 · The RIRR process that mediates rapid systemic signaling in plants is thought to involve the enhanced production of ROS by one cell that triggers the enhanced production of ROS by a neighboring cell in a process that propagates the enhanced “ROS production state” all the way from one part of the plant to another (Fig. 1 B). In contrast to ...

This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific ...

2010年1月29日 · The RD-RIRR model illustrates how local neighbor-neighbor interactions (1–2 µm distance) can lead to long distance spatiotemporal patterns. Mechanistically, in cell-wide mitochondrial oscillations, propagation is mediated by …

2021年1月1日 · Reactive oxygen species (ROS) derived from both nicotinamide adenine dinucleotide phosphate oxidase (NOX) and mitochondria play a critical role in many physiological and pathological processes. However, how highly diffusible ROS produced from different sources can coordinate to drive angiogenesis and other responses is poorly understood.

Generated ROS can be released into cytosol and trigger RIRR in neighboring mitochondria. This mitochondrion-to-mitochondrion ROS-signaling constitutes a positive feedback mechanism for enhanced ROS production leading to potentially significant mitochondrial and cellular injury.

2018年7月1日 · RIRR is a process in which one cellular compartment or organelle generates or releases ROS, triggering the enhanced production or release of ROS by another compartment or organelle.

Because the mechanism of mitochondrial RIRR highlights the central role of mitochondria-formed ROS, we discuss all of the known ROS-producing sites (shown in vitro) and their relevance to the mitochondrial ROS production in vivo.