2017年7月24日 · ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be explored. ... RMG1 cells were cultured in 1:1 ...

2021年1月11日 · Because mutations in ARID1A and TP53 are typically mutually exclusive 24,25 and p53 is extensively ... (RMG1 cells, 20,000 per well; OVCA429 cells, 10,000 per well) were seeded in XF96 Cell ...

To explore the potential role of ARID1A in regulating metabolic reprogramming, we knocked out ARID1A in ARID1A wildtype RMG1 OCCC cells to mimic loss of ARID1A protein expression caused by >90% of ARID1A mutations ... Indeed, GLS1 is expressed at a significantly higher levels in TP53 wildtype tumors with mutations in the SWI/SNF complex ...

2021年10月16日 · Identification of PARGi sensitive and resistant ovarian cancer cell lines. To analyse the molecular mechanisms underlying PARGi sensitivity, we assembled a panel of ten ovarian cancer cell lines: OVMANA, Kuramochi, OVISE, RMG1, OV56, CAOV3, COV362, OVCAR3, OVSAHO and COV318 (Fig. 1A). While six of these cell lines have genetic hallmarks of HGSOC, in particular TP53 mutations (Fig. 1A), OVMANA ...

RMGI; RMG1; RMG-1: Accession: CVCL_1662: Resource Identification Initiative: To cite this cell line use: RMG-I (RRID:CVCL_1662) Comments: Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Japanese.

2023年4月25日 · 辛伐他汀治疗显著降低了arid1a敲除rmg1细胞形成的原位异种移植的负担。相比之下，对照组rmg1细胞形成的肿瘤生长无显著影响(图6a-b)。arid1a突变的tov21g细胞形成的原位异种移植瘤也观察到类似的生长抑制(图6c-d)。

2016年12月13日 · Silencing of ARID1A using siRNA significantly sensitized HCT116 TP53 −/ ... sensitive to both VE-821 and VX-970 than the ARID1A wild-type OCCC cell line RMG1 (Fig. 3g, P<0.0001, ANOVA and ...

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The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is hosted by the National Cancer Institute (NCI) of the United …

2024年2月10日 · 主要特征反映了肿瘤、组织和培养细胞中异染色质和rt程序结构域的重塑，并与细胞增殖基因的高表达密切相关。区域突变与肿瘤抑制基因 rb1 和 tp53 的活性丧失有关，这与它们在细胞周期控制中的作用一致，这两个基因产生了不同的突变模式。突变中区域异质性 ...