Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN) -induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export. [5][6] RNase L is an enzyme that in humans is encod...

2024年12月25日 · RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of …

2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its …

2025年1月4日 · Title: RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.

Analysis of the RNASEL gene in familial and sporadic prostate cancer. A total of six variants were identified, including one intronic and five exonic changes (three missense and two silent alterations). RNASEL may function as a tumor suppressor in prostate cancer.

该基因编码干扰素调节的 2-5A 系统的一个组成部分，该系统在干扰素的抗病毒和抗增殖作用中发挥作用。 该蛋白参与先天免疫，对多种 RNA 病毒具有活性，包括流感病毒和 SARS-CoV-2 病毒。 该基因的突变与前列腺癌的易感性有关，并且该基因是遗传性前列腺癌 1 (HPC1) 等位基因的候选基因。 [RefSeq 提供，2021 年 11 月] This gene encodes a component of the interferon-regulated 2-5A system that functions in the Antiviral and antiproliferative roles of interferons.

RNase-L is a mediator of type 1 interferon-induced antiviral activity that has diverse and critical cellular roles, including the regulation of cell proliferation, differentiation, senescence and apoptosis, tumorigenesis, and the control of the innate immune response.

RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances.

RNASEL (念“R-N-ace-L”)克利夫兰医院的西尔维曼 (Robert Silverman)说：以前已知道正常型的RNASEL基因能让细胞在某些情况下产生自杀行为，这也许可以解释它与癌症之间的关系。 细胞自杀的一个原因是它正开始变得有致癌性。 如果RNASEL基因有缺陷，它就不能发放正常的自杀信号，就对癌症失去了类似“刹车”一样的能力。 论文主要作者、人类基因研究所的特伦特 (Jeffrey Trent)还说：有缺陷的RNASEL基因可能让 前列腺癌 更富侵袭性。 RNASEL (念“R-N-ace-L”) …

2016年9月14日 · Gene target information for RNASEL - ribonuclease L (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.