2024年12月25日 · RNASET2 (Ribonuclease T2) is a Protein Coding gene. Diseases associated with RNASET2 include Leukoencephalopathy, Cystic, Without Megalencephaly and Basal Ganglia Calcification, Idiopathic, 6. Among its related pathways are Innate Immune System and Pathways of nucleic acid metabolism and innate immune sensing.

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene. [5][6] It is a type of endoribonuclease. This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [6] .

2021年3月25日 · RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. However, the mechanisms underlying the regulation of RNASET2 protein are completely unknown. Here...

2021年11月11日 · Rnaset2−/− mice demonstrate upregulation of interferon-stimulated genes and concurrent IFNAR1-dependent neuroinflammation, with infiltration of CD8 + effector memory T cells and inflammatory...

The RNASET2 gene provides instructions for making a protein called ribonuclease T2 (RNAse T2), which is abundant in the brain. Learn about this gene and related health conditions.

RNASET2, an IBD susceptibility gene, is a component of TL1A-mediated pathways regulating cytokine production. Biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation.

这种核糖核酸酶基因是胞外核糖核酸酶 Rh/T2/S-糖蛋白类的一个新成员。 它是一个映射到 6q27 的单拷贝基因，6q27 是一个与人类恶性肿瘤和染色体重排相关的区域。 [RefSeq 提供，2008 年 7 月] This ribonuclease gene is a novel member of the …

2023年9月7日 · RNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function in clear cell renal cell carcinoma (ccRCC) is still not well understood.

Here, we provide a detailed survey on the highly pleiotropic oncosuppressive roles played by the human RNASET2 gene, whose protein product has been consistently reported to establish a functional crosstalk between ovarian cancer cells and key cellular effectors of the innate immune system (the monocyte/macrophages lineage), which is in turn able...

RNaseT2 (encoded by RNASET2) is a lysosomal endonuclease that cleaves single-stranded ribonucleic acid into mono- or oligonucleotides with preference for polyA and polyU, compared with polyG or polyC oligonucleotides. In humans, pathogenic mutations in RNASET2 lead to familial cystic leukoencephalopathy (see Fig. 5).