Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic … J Schulz-Fincke, M...

Faarfannoota Roobaa Amaan የሮባ አማን ምርጥ ኦሮምኛ ቆየት ያሉ ዝማሬዎች Wemenfesawi is a Geez word for a Spiritual. It is a Hub for a recorded Audio Bible in Amharic, an Amharic Biblical Quiz, Gospel Music...

2021年5月6日 · This review classifies drug-design strategies successfully implemented in the development of histone deacetylase (HDAC) inhibitors, which have many applications including cancer treatment. Our focus is on especially demanded selective HDAC inhibitors and their structure-activity relationships in relation to corresponding protein structures.

2010年11月12日 · GOD bless you Roobaa

2018年6月21日 · Reversible lysine deacetylation is exerted by both zinc and NAD + -dependent deacetylases. It is an important factor in epigenetic regulation and more generally in the posttranslational regulation of protein stability, association and activity. Some of these enzymes can also cleave off fatty acids or dicarboxylic acids from lysines in proteins.

Some aspects of the urban climates of Greater Cairo Region, Egypt. AM El Kenawy, M Hereher, SM Robaa, MF McCabe, JI Lopez-Moreno, ...

2017年6月22日 · Globally, this is pushing discovery research of antiparasitic drugs toward new agents endowed with new mechanisms of action. By using a "drug repurposing" strategy, histone deacetylase inhibitors (HDACi), which are presently clinically approved for cancer use, are now under investigation for various parasite infections.

2016年9月16日 · We applied an iterative virtual screening campaign, encompassing structure- and ligand-based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors.

2022年7月19日 · Here, we present the first fluorescent enzymatic conversion assay for HDAC10 using an aminocoumarin-labelled acetyl-spermidine derivative to measure its PDAC activity, which is suitable for high-throughput screening. Using this assay, we identified potent inhibitors of HDAC10-mediated spermidine deacetylation in vitro.

Prof. El-Sayed M. Robaa (S. M. Robaa) Astronomy, Space Sciences and Meteorology Department, Faculty of Science. Cairo University, Egypt. Professor. Email: [email protected], [email protected], [email protected]. Qualifications. 1999 Ph.D., University of Cairo, Urban Climatology. 1995 M.Sc., University of …