2022年3月14日 · Here, we report soluble Robo4 is the product of constitutive ectodomain shedding of endothelial cell surface Robo4 by disintegrin metalloproteinases ADAM10 and ADAM17 and acts to inhibit...

2024年12月25日 · ROBO4 (Roundabout Guidance Receptor 4) is a Protein Coding gene. Diseases associated with ROBO4 include Aortic Valve Disease 3 and Marfan Syndrome And Marfan-Related Disorders. Among its related pathways are Development Slit-Robo signaling and Netrin-UNC5B signaling pathway.

2024年2月21日 · Roundabout guidance receptor 4 (Robo4) is a transmembrane protein exclusive to endothelial cells and is vital in preserving vascular integrity. Hence, the hypothesis is that Robo4 maintains the...

2003年9月1日 · We show that Robo4 binds Slit and inhibits cellular migration in a heterologous expression system, analogous to the role of known Robo receptors in the nervous system. Immunoprecipitation studies indicate that Robo4 binds to Mena, a known effector of …

2024年5月18日 · In this study, using RNA-seq analysis, we found that ROBO4 downregulates prostaglandin-endoperoxide synthase 2 (PTGS2), which encodes cyclooxygenase-2. Mechanistic analysis reveals that ROBO4...

Robo4 is an endothelial-specific receptor that participates in endothelial cell migration, proliferation, and angiogenesis and the maintenance of vasculature homeostasis. The purpose of this review is to summarize and analyze three main mechanisms related to the expression and function of Robo4 during developmental and pathological angiogenesis.

Here, we report the identification of variants in ROBO4 (which encodes a factor known to contribute to endothelial performance) that segregate with disease in two families. Targeted sequencing of ROBO4 showed enrichment for rare variants …

2025年2月8日 · Robo 4 is a tumor endothelial marker expressed in the vascular network of various tumor entities. Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer. GM-CSF and IL-1beta.

2011年1月18日 · Robo4 −/− mice are viable, but exhibit increased basal and VEGF-induced retinal vascular permeability and show hypervascularization during experimentally induced pathological ocular neovascularization (Jones et al., 2008). These data suggest that Robo4 is required to maintain blood vessel integrity by counteracting VEGF and acts as a ...

"Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–67. doi: 10.1016/S0012-1606 (03)00258-6. PMID 12941633.