Reactive oxygen species and cell signaling. Review
2024年2月1日 · Normal ROS levels are essential for cellular processes, known as oxidative eustress. Oxidants activate ASK1, JNK, p38 and ERK MAPKs, and PI3K/Akt signaling …
ASK1在氧化应激条件下的激活 | MedChemExpress - 知乎
ASK1 是一种广泛表达的氧化还原敏感性丝氨酸/苏氨酸激酶，可激活 p38 和 c-Jun N 末端激酶 (JNK)MAPKKs，并诱导细胞凋亡，炎症和纤维化信号传导。 在氧化应激状态下 ASK1 激活 …
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is
2005年5月1日 · ASK1 formed a complex with TRAF6 in response to LPS, and this complex formation and subsequent ASK1 activation required LPS-induced production of reactive …
Amyloid β induces neuronal cell death through ROS-mediated ASK1 …
2004年12月9日 · Reactive oxygen species (ROS), nitric oxide and endoplasmic reticulum (ER) stress have been implicated in A β -induced neurotoxicity. We have reported that apoptosis …
Ask1 and Akt act synergistically to promote ROS-dependent ... - PubMed
2019年1月24日 · Our findings demonstrate a non-autonomous activation of a ROS sensing mechanism by Ask1 and Akt1 to replace the missing tissue after damage. Collectively, these …
The ASK1–MAP kinase pathways in immune and stress responses
2006年4月1日 · ASK1 is activated in response to various stimuli including LPS, ROS, ER stress, influx of calcium ions and various cytokines such as tumor necrosis factor and Fas ligand. We …
Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to
2014年1月21日 · Apoptosis signal–regulating kinase 1 (ASK1, also known as MAP3K5) mediates reactive oxygen species (ROS)–induced cell death. When activated by ROS, ASK1 ultimately …
Small-molecule inhibitors targeting apoptosis signal-regulated …
2023年12月15日 · ASK1 activity is triggered in response to multiple stressors, including endoplasmic reticulum (ER) stress, lipopolysaccharides (LPS), calcium influx and tumor …
Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1 …
2019年8月5日 · Inhibition of ROS with N-acetyl cysteine (NAC) significantly decreased pristimerin-induced cell death by inhibiting the phosphorylation of ASK1 and JNK. Taken together, these …
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is …
Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we …