ROS promote the activation of c-Jun N-terminal kinase (JNK) and DNA damage response, which establishes a positive feedback loop with p53. This converts the p53-induced growth arrest/senescence to apoptosis.

2006年3月15日 · In this review we will first summarize and discuss some recent findings regarding the signaling mechanisms of ROS-or RNS-mediated JNK activation. Second, we will talk about the role of JNK in ROS-or RNS-mediated cell death (both apoptosis and necrosis).

2011年10月27日 · 摘要：c-JunN端激酶 (JNK)通路是细胞感受外界环境变化的重要途径，与细胞增殖、分化、凋亡等生命过程息息相关。 活性氧 (ROS) 具有很高的生物学活性，可作为第二信使参与到JNK信号通之中。 ROS可通过ASK1、Src激酶、GSTπ、MLK3、RIP-TRAF2复合. 体、MKPs等信号蛋白活化JNK，也可以充当IKK/NF-κB、ERK等信号通路与JNK信号通路交叉对话的桥梁。 另外JNK有时可. 出现在ROS上游，可通过促进ROS产生或聚集而发挥生物学作用。 本 …

2024年2月1日 · Reactive oxygen species (ROS) activate JNK, p38 and ERK mitogen-activated protein kinases (MAPK), which upregulate c-Jun and c-Fos expression at the transcriptional level. Expression of c-Jun, a target gene of Jun/AP-1, increases through JNK-induced transactivation.

2005年12月9日 · Further studies have also revealed that NF- κ B inhibits JNK activation by suppressing accumulation of reactive oxygen species (ROS). In this review, we will focus on the signaling crosstalk...

ROS are involved in regulating the activation of c-Jun N-terminal kinase (JNK)/nuclear factor kappa-B (NF-κB) signaling molecules. When the signaling molecules are overactivated by ROS, the internal environment of the body can be disturbed.

2006年3月15日 · In this review, we aim to summarize recent findings on the regulatory role of ROS and RNS in JNK activation, especially on the following aspects: (i) the molecular mechanisms of ROS-or RNS-mediated JNK activation processes, (ii) the role of JNK in oxidative or nitrosative stress-mediated cell death (both apoptosis and necrosis), and (iii) the ...

2015年10月23日 · Propagated ROS activate p38 and induce tolerable levels of JNK. The activation of JNK and p38 results in the expression of the cytokines Unpaired (Upd), which triggers the JAK/STAT signaling pathway required for regeneration. Our findings demonstrate that this ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis.

c-junn端激酶(jnk)通路是细胞感受外界环境变化的重要途径,与细胞增殖、分化、凋亡等生命过程息息相关.活性氧(ros)具有很高的生物学活性,可作为第二信使参与到jnk信号通之中.ros可通过ask1、src激酶、gstπ、mlk3、rip-traf2复合体、mkps等信号蛋白活化jnk,也可以充当ikk ...

2024年5月6日 · It was found that reactive oxygen species (ROS)-mediated JNK signaling pathway is closely associated with oxidative stress. Sánchez-Chávez et al. have shown that JNK1/2 phosphorylates its downstream target, c-Jun, to reduce insulin synthesis through regulating ROS stimulation in β-cells.