一、线粒体膜电位（mmp）介绍线粒体是动植物细胞生成atp的主要地点，是促进细胞能量转换、参与细胞凋亡的重要细胞器。 线粒体在呼吸氧化过程中，将所产生的能量以电化学势能储存于线粒体内膜，在内膜两侧造成质子及…

2022年10月22日 · 大量研究表明，以线粒体通透性转换孔（mptp）开放和活性氧（ros）水平升高、线粒体膜电位（mmp）降低为表现的线粒体功能障碍在神经性疼痛的发生发展中起重要作用。

2018年10月3日 · Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen species (mtROS), that regulates MMP9 expression and may be a target to suppress cancer metastasis.

In this chapter, we describe a relation between mitochondrial membrane potential and the rate of ROS formation. We present different methods applicable for isolated mitochondria or intact cells. We also present experiments demonstrating that a magnitude and a direction (increase or decrease) of a change in mitochondrial ROS production depends ...

2020年7月20日 · ROS and the stress kinase JNK mediate the accumulation of matrix metalloproteinase 2 (Mmp2), damaging the BM, which recruits macrophages to the tissue. We propose a model where macrophage...

2017年8月14日 · Matrix metalloproteinase (MMP) is defined as an endopeptidase in the extracellular matrix (ECM), which plays essential roles in physiological processes such as...

2004年9月15日 · Studies from several independent groups suggest that ROS converge on the matrix metalloproteinase family members by regulating both MMP gene expression and MMP activation. This report summarizes the important ROS-sensitive signaling pathways that contribute to MMP gene expression.

2020年9月17日 · Our study showed that MMP9 expression correlates with the reduced ROS levels, decreased DNA damage, and upregulated mismatch repair pathway. This suggests that MMP9 expression is a natural...

2016年6月1日 · Putative mechanisms of ROS-induced MMP. ROS can directly oxidise components or regulators of the PTP such as F O F 1 ATPase, VDAC and ANT. ROS also induce p53- or JNK-mediated activation of CypD or of Bax/Bak oligomerisation. Through p53 or JNK activation, ROS inhibit anti-apoptotic Bcl-2 family members.

Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen species (mtROS), that regulates MMP9 expression and may be a target to suppress cancer metastasis.