2024年1月12日 · In recent years, many studies have indicated that ROS play crucial roles in regulating ultraviolet (UV)-induced photodamage of the skin, including exogenous aging, which accounts for 80% of aging. However, to the best of our knowledge, the detailed signaling pathways, especially those related to the mechanisms underlying apoptosis in which ROS ...

More specifically UV light can induce ROS by affecting the enzyme catalase and up-regulating nitric oxide synthase (NOS) synthesis. It may also cause a decrease in protein kinase C (PKC) expression leading to increased ROS production. UVR is capable of modifying DNA and other chromophores resulting in elevated ROS levels.

2021年7月27日 · An increasing evidence showed that the elevated ROS/RNS production, especially due to UV irradiation, are associated with pigmentation and aging in the skin. ROS/RNS play key roles in skin damage and melanogenesis signaling pathways, and they contribute to the oxidation and/or polymerization of pre-existing melanin or …

2024年3月1日 · The principal pathogenic effects of UV radiation on the skin involve the generation of ROS and genetic mutations. Among the various components of solar radiation, UVA frequently leads to the accumulation of ROS in the skin, causing alterations in …

ROS is generated when skin is exposed to ultraviolet rays and visible light. In the presence of photosensitizers, such as psoralen, porphyrin, and tetracycline, oxygen reaches its highest excited state via photoreaction pathways, resulting in the formation of …

2017年11月9日 · Broadly UV can induce ROS by affecting the cellular components directly or by means of photosensitization mechanisms. More specifically UV light can induce ROS by affecting the enzyme catalase and up-regulating nitric oxide synthase (NOS) synthesis.

UV-B radiation directly causes mutations in DNA; UV-A predominantly acts indirectly via the generation of ROS in lipid rafts of cell membranes. IR-A is mainly absorbed in mitochondria and...

2024年1月12日 · In recent years, many studies have indicated that ROS play crucial roles in regulating ultraviolet (UV)-induced photodamage of the skin, including exogenous aging, which accounts for 80% of aging. However, to the best of our knowledge, the detailed signaling pathways, especially those related to the mechanisms underlying apoptosis in which ROS ...

2020年6月15日 · UV radiation can cause skin complications by increasing ROS production 6, 7, and by oxidising squalene 8, 9 and other proteins 10. Moreover, carbonylated protein levels in the stratum corneum...

Inflammation and the resulting accumulation of reactive oxygen species (ROS) play an important role in the intrinsic and photoaging of human skin in vivo. Environmental insults such as ultraviolet (UV) rays from sun, cigarette smoke exposure and pollutants, and the natural process of …