My lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently we are focused on members of the serotonin (5-hydroxytryptamine; 5-HT) and opioid receptor families and their accessory proteins.

Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine. [1] He is recognized for his discoveries and inventions in the general areas of molecular pharmacology, GPCR structure, and function and synthetic neurobiology.

Welcome to the Roth Lab! The Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). For more specific information check out our research page. The Roth lab is the principal contractor for the NIMH Psychoactive Drug Screening Program which includes the PDSP Ki database.

Automated design of ligands to polypharmacological profiles. Nature 492: 215-220, 2012 (*Corresponding authors) Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. BL Roth, SC Craigo, MS Choudhary, A Uluer, FJ Monsma, Y Shen, ... J Besnard,...

TRUPATH measures heterotrimeric G protein dissociation by bioluminescence resonance energy transfer 2, or BRET2, between an alpha subunit-fused RLuc8 and gamma subunit-fused GFP2 that requires the substrate coelenterazine 400a or methoxy e-coelenterazine and is spatially- and orientationally- dependent.

2016年2月17日 · Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now commonly used by neuroscientists to identify the circuitry and cellular signals that specify behavior, perceptions, emotions, innate drives, and motor functions in species ranging from flies to nonhuman primates.

Roth BL, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006 .

2023年12月6日 · 近日， Tao Che 和 Bryan L. Roth 两人 梳理了阿片类受体信号传导的分子机制，特别关注内源性肽或药理剂与受体结合的结构特征。 这些研究成果不仅阐释了配体选择性的关键互动，还为研发具有特殊药理特性的新型止痛药提供了线索。 最后，生物化学和计算生物学的结合，正加速新型化合物的发现，期望未来能带来更有效、更安全的阿片类止痛药。 他们的成果发表在最新一期的 Cell 杂志上，名为 “Molecular basis of opioid receptor signaling” 16世纪，人们对 …

2023年11月22日 · Here, we review the molecular basis of opioid receptor signaling with a focus on the structures of opioid receptors bound to endogenous peptides or pharmacological agents. These insights unveil specific interactions that dictate ligand selectivity and likely their distinctive pharmacological profiles.