IRE1α RIDD activity induced under ER stress drives neuronal death …
2021年6月3日 · Three ER-resident transmembrane proteins orchestrate the UPR: inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and protein kinase RNA …
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α …
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · Nature Communications - IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent …
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in …
2024年10月16日 · IRE1α RNase silences taxane-induced double-stranded RNA (dsRNA) through regulated IRE1-dependent decay (RIDD) to prevent NLRP3 inflammasome-dependent …
The ER stress sensor IRE1 interacts with STIM1 to promote store ...
2023年12月26日 · Our findings unveil a direct crosstalk between SOCE and UPR via IRE1, acting as key regulator of ER Ca 2+ and proteostasis in T cells and muscles. Under ER stress, this …
Fat body Ire1 regulates lipid homeostasis through the Xbp1s …
Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic …
IRE1 prevents endoplasmic reticulum membrane permeabilization …
2015年6月23日 · IRE1 is a transmembrane protein with kinase and RNase activities that is localized to the ER and that promotes resistance to ER stress. We showed a mechanism by …
IRE1α Cleaves Select microRNAs During ER Stress to Derepress ...
2012年10月4日 · UPR signaling requires IRE1α, an ER transmembrane kinase-endoribonuclease (RNase) that becomes activated by unfolded protein accumulation within the ER and excises a …
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α …
Getting RIDD of RNA: IRE1 in cell fate regulation - ScienceDirect
2014年5月1日 · Here we review recent findings on RIDD and propose a model of how IRE1 RNase activity might control cell fate decisions. The ER is an organelle comprising a luminal …