2024年12月25日 · RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) is a Protein Coding gene. Diseases associated with RUNX1T1 include Acute Myeloid Leukemia With T (8;21) (Q22;Q22) Translocation and Hematologic Cancer. Among its related pathways are Acute myeloid leukemia and Wnt/beta-catenin signaling pathway in leukemia.

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. [5][6][7] The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities.

2022年7月28日 · RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute myeloid leukemia.

runx1t1（runt 相关转录因子 1，易位为 1）是骨髓易位基因 (mtg) 家族成员，通常作为融合蛋白 runx1-runx1t1 的一部分进行研究，因为它在急性髓细胞白血病中的作用。

RUNX1/RUNX1T1 regulates gene expression at multiple levels. The fusion protein can dysregulate transcription by binding to promoter, enhancer, or silencer elements. RUNX1/RUNX1T1 also affects the ratios of RNA isoforms by regulating alternative promotor activity and affecting RNA splicing.

2021年1月22日 · The fusion oncogene RUNX1/RUNX1T1 encodes an aberrant transcription factor, which plays a key role in the initiation and maintenance of acute myeloid leukemia.

2025年1月9日 · Here, we present detailed clinical and genetic data from three individuals identified with de novo variants in RUNX1T1. These cases illustrate a diverse array of phenotypic manifestations, ranging from developmental delay and speech impairments to distinct craniofacial and physical anomalies.

2020年1月14日 · In this review, we present an up-to-date overview of the molecular features of this subtype of AML, focusing on the disruption caused by RUNX1-RUNX1T1 fusion, the cooperating mutations that have been uncovered, the activation of oncogenes and signaling pathways, and the role of microRNAs (miRs).

关于 runx1t1 Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:91,954,967-92,103,385 (from NCBI) This gene has 52 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 92 phenotypes.

2025年2月19日 · RUNX1T1, a potential prognostic marker in breast cancer, is co-ordinately expressed with ERalpha, and regulated by estrogen receptor signalling in breast cancer cells. AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms.