Ryanodine receptors (RyR for short) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. [1] There are three major isoforms of the ryanodine receptor, which are found in different tissues and participate in different signaling pathways involving calcium release from intracellular ...

Ryanodine受体（RyR）是存在于内质网/肌浆网上（ER/SR）的一种钙释放通道。它能迅速地将Ca2+从ER/SR中释放出来, 从而发挥一系列的生理功能。Ryanodine受体对保持胞内钙的平衡也起着重要作用。

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca 2+ from intracellular stores during excitation-contraction coupling in both cardiac and skeletal muscle.

2018年2月1日 · Ryanodine receptors (RyR) are intracellular ion channels that act as conduits for the regulated release of stored Ca 2+ to affect diverse cellular processes. Initially identified as ‘feet’ structures in the sarcoplasmic reticulum (SR) of native tissue [ 1 , 2 ], the molecular characterization of the channel was facilitated by virtue of its ...

Ryanodine receptors (RyRs) are the largest ion channels presently known. They are very large (2.2 MDa) Ca channels that play a key role in excitation-contraction (EC) coupling [1, 2, 3, 4, 5]. RyRs are present in all animals [6, 7]. Three RyR isoforms have been identified in mammals: RyR1, RyR2 and RyR3.

2020年2月17日 · Ryanodine receptors (RyR) are ion channels responsible for the release of Ca 2+ from the sarco/endoplasmic reticulum and play a crucial role in the precise control...

Ryanodine receptors (RyRs), homotetrameric intracellular Ca 2+ release channels composed of four 565 kDa (~5,000 amino acids) protomers, are found on the sarcoplasmic/endoplasmic reticulum (SR/ER) of virtually all cell types (1).

2021年6月1日 · The elucidation of synergistic activation sites on RyR is essential for understanding the wide-ranging implications of RyR modulation for myocyte contractility and calcium dynamics. Thus, the recent structural work on RyR modulators reveals a wealth of information that will aid in further study of calcium dynamics and SR regulation in skeletal ...

2012年9月14日 · Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of Ca2+ from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom-like shape, consisting of a large cytoplasmic head and transmembrane stalk.

2021年12月10日 · While sustained leaky RyRs may be involved in pathological conditions, recent findings in healthy people engaging in exercise training suggest that an acute transient SR Ca 2+ leak via RyR ...