Here, employing fluorescent probes and a tool for triggering ectodomain shedding, we show that epiregulin (EREG), a low-affinity EGFRL, rapidly and efficiently activates EGFR in Madin …

2014年2月13日 · In this study, we describe the unexpected deposition of Erk2 on developmental promoters, as well as the corresponding decrease in RNAPII(S5P) upon Erk1/2 inactivation. …

Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and …

2024年6月15日 · Here, we show that an EGFR endocytic mechanism, non-clathrin endocytosis (NCE), which is activated only at high ligand concentrations and targets receptor to …

2025年2月19日 · EGF binds EGFR, and promotes p-ERK activation, which increases the expression of mesenchymal marker ZEB1 and decreases the expression of the epithelial …

2020年8月11日 · Here, we developed a model explicitly accounting for conformational changes of the kinase and extracellular domains, their dimerizations and ligand binding to monomeric and …

2008年6月1日 · EGFR activation underlies the hyperproliferative effects of retinoids on skin keratinocytes. Indeed HB-EGF is markedly induced in keratinocytes in response to retinoid …

2003年3月10日 · The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, …

2023年12月3日 · The binding of soluble EGF ligands to the extracellular domain promotes receptor activation. The epidermal growth factor receptor (EGFR) family is a subclass of …

2018年10月1日 · Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR) has progressed rapidly in recent times. New crystal structures of the …