p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1,2). p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs (1).

Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. [5] [6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7]

2024年12月4日 · p70核糖体蛋白S6激酶（p70S6K），全称为70 kDa ribosomal protein S6 kinase，是一种丝氨酸/苏氨酸蛋白激酶，属于AGC激酶家族。 p70S6K在细胞内扮演着重要的信号传导角色，尤其是在mTOR（哺乳动物雷帕霉素靶蛋白）信号通路中，作为mTOR的主要下游效应 …

2011年1月1日 · The 70 kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients. The S6 kinases have been linked to diverse cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth and survival.

The 70 kDa ribosomal S6 kinase (pp70S6k) plays an important role in the progression of cells through G1 phase of the cell cycle. However, little is known of the signaling molecules that mediate its activation. We demonstrate that Rho family G …

The 70kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients. The S6 kinases have been linked to diverse cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth and survival.

2012年1月1日 · 核糖体蛋白 s6k（s6 激酶）代表了 torc1 [tor（雷帕霉素靶点）复合物 1] 的一种广泛研究的效应物，其在细胞和生物体生理学中具有重要但尚未完全确定的作用。

The 70/85 kDa ribosomal protein S6 kinase is regulated through the concerted actions of multiple phosphatases and kinases. A newly identified S6 kinase kinase, NEK6, appears to provide the penultimate activation step.

1995年1月1日 · The past year has revealed the complexity of pp70 S6k regulation, with the overriding theme being that enzymes which have proven or putative roles in phospholipid metabolism mediate its activation. Studies also indicate that pp70 S6k may regulate many more pathways than previously recognized.

Phospho-p70 S6 Kinase (Thr389) (108D2) Rabbit mAb detects endogenous levels of p70 S6 kinase only when phosphorylated at Thr389. This antibody also detects p85 S6 kinase when phosphorylated at the analogous site (Thr412) and possibly S6KII phosphorylated at Thr388.