P70-S6 Kinase 1 - Wikipedia
Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. …
Beyond controlling cell size: functional analyses of S6K in ...
2022年7月25日 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have …
The mTORC1 effectors S6K1 and 4E-BP play different roles in
2014年11月10日 · Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that activation of the mammalian target of rapamycin complex 1 (mTORC1) in …
「珍藏版」Cell综述｜细说mTOR底物磷酸化 - 百家号
mtorc1及其直接效应子s6k在不同部位磷酸化irs1以抑制胰岛素信号传导。mtorc1还直接磷酸化并激活grb10。因此，mtorc1下调pi3k信号通路以抑制mtorc2活性。s6k还分别磷酸化ricrtor …
体型控制器：S6K1 - 知乎 - 知乎专栏
S6K1（Ribosomal protein S6 kinase beta-1） 主要由三个结构域组成，分别是N端结构域（NTD）、中间激酶结构域（KD）和C端自抑制结构域（CTD）（如图1）。 S6K1具有两种 …
mTOR 信号网络中核糖体蛋白 S6 激酶 (S6K) 的调节和功能 …
2012年1月1日 · 核糖体蛋白 S6K（S6 激酶）代表了 TORC1 [TOR（雷帕霉素靶点）复合物 1] 的一种广泛研究的效应物，其在细胞和生物体生理学中具有重要但尚未完全确定的作用。 …
Direct imaging of the recruitment and phosphorylation of S6K1 …
2019年3月4日 · Within this pathway we have focused on S6 kinase 1 (S6K1), the downstream phosphorylation substrate of mTORC1, and specifically identify its juxtaposition with mTORC1. …
Regulation and function of ribosomal protein S6 kinase (S6K) …
2012年1月1日 · The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet …
mTOR and S6K1 Mediate Assembly of the Translation ... - Cell Press
2005年11月18日 · We show that mTOR and S6K1 maneuver on and off the eukaryotic initiation factor 3 (eIF3) translation initiation complex in a signal-dependent, choreographed fashion. …
The S6K protein family in health and disease - ScienceDirect
2015年6月15日 · S6K is the only AGC kinase that is a mTORC1 substrate. S6K1 was originally identified as the kinase for ribosomal protein S6, but is now known to have many more …
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