p70核糖体s6激酶 (s6k) 和真核起始因子eif4e的结合蛋白 4ebp。它们各自通过下游的效应子来分别促进帽依赖的翻译及ejc相关的翻译。其中s6k的激活会磷酸化并降解胰岛素受体底物irs1，从 …

Akt 激活后可通过抑制 GSK-3 诱导糖原合成；通过 mTOR 和下游成分进行蛋白质合成；通过抑制多个促凋亡因子（Bad、FoxO 转录因子、GSK-3 和 MST1）促进细胞存活。

2011年11月11日 · Here we provide evidence for two mechanisms of modulating turn motif phosphorylation and S6K1 activity. First, mammalian target of rapamycin regulates turn motif …

2020年4月1日 · GSK-inactivating kinases include Akt, 90-kDa ribosomal S6 kinase (p90RSK), 70-kDa ribosomal S6 kinase 1 (p70S6K1), and protein kinase A (PKA) [18]. In contrast, the two …

2011年11月22日 · The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle. …

The GSK-3 signaling pathway was reported to regulate autophagy flux via the mTORC1, PKC and AKT signaling pathways [30,61,65,78,111]. mTORC1, known as a major autophagy regulator, …

A rapamycin-sensitive pathway, most likely acting via ribosomal 70-kDa protein S6 kinase (p70(S6K)), has also been implicated in the regulation of GSK-3 and GS by insulin. Amino …

Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of...

thase kinase (GSK)-3 promotes turn motif phosphorylation. Our studies show that mammalian target of rapamycin and GSK-3 cooperate to control the activity of S6K1, an important …

2022年7月25日 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have …