SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in …

2024年12月25日 · Complete information for SAMHD1 gene (Protein Coding), SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1, including: function, …

2018年4月18日 · Here we show that SAMHD1 promotes degradation of nascent DNA at stalled replication forks in human cell lines by stimulating the exonuclease activity of MRE11. This …

2014年2月13日 · SAMHD1 encodes the sterile α motif and histidine-aspartic domain (HD) containing protein 1, a deoxynucleoside triphosphate triphosphohydrolase that degrades the …

SAMHD1 is a dNTPase Comprised of an N-terminal SAM Domain, a Central HD Domain, and C-Terminal Regulatory Domain.

2020年3月31日 · Recent publications have identified diverse roles for SAMHD1 in double-stranded break repair, genome stability, and the replication stress response through interferon …

SAMHD1 is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is …

The SAMHD1 gene provides instructions for making an enzyme that helps cut molecules called deoxynucleoside triphosphates (dNTPs). Learn about this gene and related health conditions.

2025年1月4日 · SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. …

2025年1月18日 · SAMHD1 is a dNTPase that impedes replication of HIV-1 in myeloid cells and resting T lymphocytes. Here we elucidate the substrate activation mechanism of SAMHD1, …