2022年1月21日 · SCP4是一种磷酸酶，即能从蛋白质中清除磷酸基团来调节细胞活性的蛋白质，另外一种名为激酶的蛋白质则能将这些磷酸基团放回去；从蛋白质上增加 ...

2025年3月3日 · Foundation Universe Hub - For information on Sites, Mobile Task Forces, Departments, and more. Audio Adaptations - Links to audio read-outs of various articles on the site. SCP Series 4 - Tales Edition - Tales associated with SCPs of this Series. SCP-3009 - Hi, I'm Your Snappelganger! SCP-3043 - Murphy Law in… Type 3043 — FOR MURDER!

We found that SCP4 enhanced the transcription of FoxO1/3a target genes encoding PEPCK1 and G6PC, key enzymes in hepatic gluconeogenesis. Ectopic expression of SCP4 increased, while knockdown of SCP4 inhibited, glucose production. Moreover, we demonstrated that gene ablation of SCP4 led to hypoglycemia in neonatal mice.

2022年1月11日 · We provide evidence that SCP4 regulates STK35/PDIK1L through two distinct mechanisms: catalytic removal of inhibitory phosphorylation and by promoting kinase stability. Our findings reveal a phosphatase-kinase signaling complex that supports the pathogenesis of AML.

2017年12月12日 · Identification of SCP4 as a key regulator of FoxOs in hepatic gluconeogenesis advances our understanding of glucose homeostasis. The study by Cao et al. (13) elegantly demonstrates the biochemical nature of the SCP4-FoxO1/3a …

SCP4 represents a novel nucleus-resident phosphatase identified in our previous study. The primary aim of this study was to elucidate the function of SCP4 in the progress of cartilage development and endochondral osteogenesis.

SCP4, also known as carboxy‐terminal domain (CTD) small phosphatase like 2 (CTDSPL2), act as a metal‐dependent serine/threonine phosphatase capable of directly dephosphorylating various targets and interacting with multiple nuclear proteins. 16 Notably, SCP4 operates as a chromatin‐associated CTD phosphatase in humans and is hypothesized ...

2023年9月8日 · Level 1 clearance is required for basic access to SCP-004-1; Level 4 clearance is required for use of SCP-004-2 to -13. Description: SCP-004 consists of an old wooden barn door (SCP-004-1) and a set of twelve rusted steel keys (SCP-004-2 through SCP-004-13). The door itself is the entrance to an abandoned factory in [DATA EXPUNGED].

Knockdown of SCP4 significantly suppressed FoxO1/3a-mediated expression of Atrogin-1 and MuRF-1 and prevented muscle wasting in mice with CKD. Thus, SCP4 is a novel regulator of FoxO transcription factors and promotes cellular proteolysis. Hence, targeting SCP4 may prevent muscle wasting in CKD and possibly other catabolic conditions.

The small C-terminal domain phosphatase 4 (SCP4), also known as carboxy-terminal domain (CTD) small phosphatase like 2 (CTDSPL2), is a novel phosphatase in the nucleus identified in our previous study. This study aimed to investigate the function of protein phosphatase SCP4 in cartilage development and endochondral osteogenesis.