SERCA is a P-type ATPase. [1] It resides in the sarcoplasmic reticulum (SR) within myocytes. [1] It is a Ca 2+ ATPase that transfers Ca 2+ from the cytosol of the cell to the lumen of the SR. [1] This uses energy from ATP hydrolysis during muscle relaxation. [1]There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form …

2023年6月8日 · SERCA2 is phosphorylated at serine 663 in both mouse and human hearts. The cardiac isoform 2 of the sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA2) plays a major role in controlling the ...

2024年12月24日 · Stabilizes SERCA2 in its E2 state (PubMed:28890335). AT2A2_HUMAN,P16615; Molecular function for ATP2A2 Gene according to GENATLAS. Biochemistry: ATPase,Ca++ transporting,expressed in the sarcoplasmic reticullum of the heart (SERCA2A) rate determining factor of Ca2+ reuptake into the SR,regulated by phospholamban,also expressed in the heart,slow ...

Intriguingly, SERCA2-dependent Ca 2+ dysregulation has been implicated in several disorders that affect cognitive function, including Darier's disease, schizophrenia, Alzheimer's disease, and cerebral ischemia. The current review summarizes knowledge on the expression pattern of the different SERCA2 isoforms in the nervous system, and further ...

2018年4月16日 · The current review summarizes knowledge on the expression pattern of the different SERCA2 isoforms in the nervous system, and further discusses evidence of SERCA2 dysregulation in various neuropsychiatric disorders. To the best of our knowledge, this is the first literature review that specifically highlights the critical role of the SERCA2 in ...

Calcium ion (Ca²⁺) cycle plays a crucial role in the contraction and relaxation of cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca²⁺, which mediated the release and re-uptake of Ca²⁺ during contraction and relaxation. Disorders of …

2024年12月17日 · SERCA2 dysregulation has been implicated in several disorders including schizophrenia, Alzheimer’s disease, and cerebral ischemia. 62 For example, studies in mammalian cell lines and X. laevis oocytes showed that mutations in the presenilin (PS) gene decreased SERCA2 activity and that modulating SERCA function altered amyloid β production ...

SERCA2 is the principal subtype of SERCA in the vasculature, responsible for maintaining calcium homeostasis by transporting Ca 2+ from the cytoplasm to the ER lumen. The major genotypes of SERCA2 are SERCA2a and SERCA2b. In …

2020年5月15日 · 多项研究证明SERCA2a能够发生PTM，并且可在不同位点发生不同类型的PTM，从而影响SERCA2a的活性及功能。 蛋白质磷酸化是指在蛋白激酶的作用下，将磷酸基团转移至靶蛋白，从而改变靶蛋白的构象…

2018年2月21日 · The SERCA2 gene is best known for encoding both the ubiquitous and cardiac-specific isoforms of SERCA (Vangheluwe et al. 2005). In all, four isoforms (SERCA2a-d) are generated by alternative splicing of the SERCA2 gene transcript. SERCA2b is a ubiquitous isoform expressed in all cell types, whereas SERCA2a is restricted to cardiac muscle, slow ...