2021年11月18日 · David MacMillan教授课题组利用双分子均裂取代（SH2）机制实现了仿生sp3-sp3键交叉偶联，构建了一系列季碳sp3-碳中心。 机理研究证实了一级烷基-Fe (III)物种在偶联之前的中介作用，并为关键的季碳sp3-碳键形成步骤中的SH2取代途径提供了证据。

The Kaman SH-2 Seasprite is a ship-based helicopter originally developed and produced by American manufacturer Kaman Aircraft Corporation. It has been typically used as a compact and fast-moving rotorcraft for utility and anti-submarine warfare (ASW) missions.

2022年11月22日 · 近日，2021年化学诺奖得主、美国普林斯顿大学的David W. C. MacMillan教授课题组首次报道了一种基于双分子均裂取代 (SH 2)策略的光/镍协同催化自由基型交叉脱羧偶联反应，可用于由脂肪族羧酸出发构建有价值的C (sp3 )-C (sp3 )偶联产物。 详细的机理实验表明该反应涉及Ni (III)-烷基物种与烷基自由基间的SH 2过程。 此外，该反应还提供了一种高效构建大位阻季碳中心的通用策略，解决了经典偶联反应中长期存在的挑战。 图1. 光/镍催化双分子均裂取代 …

SuperH (or SH) is a 32-bit reduced instruction set computing (RISC) instruction set architecture (ISA) developed by Hitachi and currently produced by Renesas. It is implemented by microcontrollers and microprocessors for embedded systems.

The SH2 (S rc H omology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein [2] and in many other intracellular signal-transducing proteins. [3] SH2 domains bind to phosphorylated tyrosine residues on other proteins, modifying the function or activity of the SH2-containing protein.

2024年8月8日 · In this review, we aim to highlight the latest breakthroughs and mechanistic insights into radical S H 2 reactions, focusing on the role of transition metal catalysts in facilitating these transformations.

将 SH2 反应与过渡金属催化合并：我们重点介绍了过渡金属催化中双分子均解取代 （SH2） 反应的最新例子。 开壳平台已成为构建 C（sp3）−C（sp3） 和 C（sp3）-杂原子键的有吸引力的多功能平台。

2024年3月21日 · In this work, we report a nickel radical sorting–mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to …

2024年1月11日 · In this work, we propose an inference-time method, Self-Highlighted Hesitation (SH2), to help LLMs decode more truthfully. SH2 is based on a simple fact rooted in information theory that for an LLM, the tokens predicted with lower probabilities are prone to be more informative than others.

SH2db is a convenient starting point for working with pre-aligned SH2 domain sequences and structures. You can Browse individual entries for proteins, specific structures and AlphaFold models, Search the database by sequence-specific criteria, and download any subset of structures as a Pymol session.