2019年3月21日 · Detailed studies reveal that HoxA10 binds to p38 MAPK, recruits SH2-containing protein tyrosine phosphatase 1 (SHP-1) to facilitate SHP-1 in catalyzing dephosphorylation of p38 MAPK/STAT3, and thereby attenuates p38 MAPK/STAT3 activation and HBV replication.

2008年4月6日 · SHP-1 inhibited TLR-initiated production of proinflammatory cytokines by suppressing the activation of MAPKs and NF-κB, but it increased TLR- and RIG-I-activated type I interferon by directly...

2013年9月1日 · SHP-1 expression was analyzed by Western immunoblotting of protein lysates from control macrophages treated with either SHP-1 scrambled or SHP-2 specific ODNs using monoclonal anti–SHP-1 Ab. The equal loading of protein was confirmed with either anti-p38 MAPK or anti-actin Abs. Results shown are from a representative experiment of at least ...

2013年1月21日 · SHP-1 作为 PTP 中重要的一员，是改变胞内磷酸化水平的关键因子，当外源性信号分子同胞膜上受体结合后激发受体分子二聚化，与受体耦联的两面神激酶（JAK）互相靠拢，通过彼此的酪氨酸磷酸化而活化，活化后 JAK 催化受体自身的酪氨酸磷酸化，形成了 SHP-1 的停泊位点。 SHP-1 与受体上的停泊位点结合而被激活，催化 JAK 的酪氨酸去磷酸化，降低激酶催化活性，进而终止信号传导。 但具体而言， SHP-1 其在不同的细胞中可产生不尽相同的胞内 …

The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental disorders with overlapping ...

详细研究表明，hoxa10与p38 mapk结合，募集含有sh2的蛋白酪氨酸磷酸酶1（shp-1），以促进shp-1催化p38 mapk / stat3的去磷酸化，从而减弱p38 mapk / stat3的活化和hbv复制。此外，hoxa10与hbv增强子i（enhi）/ x启动子结合，与stat3竞争该启动子的结合，从而抑制hbv转录。

These results suggest that FCRL3 can activate the SHP-1 and p38 MAPK pathways and then promote the secretion of IL-10 in B cells, thus inhibiting the secretion of inflammatory factors. Therefore, FCRL3 may play an immunoprotective role in MS, and it will be an effective target for the diagnosis and treatment of MS.

2013年9月1日 · The results reveal that tyrosine kinases Src and proline-rich tyrosine kinase 2 (Pyk2) regulate SHP-1-dependent LPS-induced IL-10 production and infer that optimal LPS-induced IL-10 production requires an assembly of a protein complex consisting of …

Download scientific diagram | Effects of SHP-1 activation on MAPK phosphorylation levels: Western blot analysis for phosphorylated MAPK (pMAPK) and total MAPK (tot MAPK) of protein...

2021年3月15日 · Thus, CagA has emerged as a negative regulator of MAPK and NF-κB signaling pathways that functions by enhancing the recruitment of SHP-1 to TRAF6. In summary, we have demonstrated that the H. pylori virulence factor CagA interacts with the host cellular protein SHP-1, which promoted the recruitment of SHP-1 to TRAF6 and inhibited the ...