In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be …

2023年10月1日 · Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective …

2020年4月1日 · Here we will review the aging-related signaling pathways in which SIRT1 participates to regulate cellular senescence, metabolic disorders, autophagy, DNA damage …

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …

Aging is a degenerative process associated with cumulative damage, which leads to cellular dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

2020年9月28日 · Our study reveals a mechanism in the regulation of the protein homeostasis of SIRT1 and suggests a potential strategy to stabilize SIRT1 to promote productive ageing. …

2021年5月28日 · Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD + -dependent SIRT6 deacylase regulates aging and metabolism …

One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, …

2016年1月19日 · A new study published in Cell Research reports a novel role for the aging-associated SIRT6 deacetylase in the control of oxidative homeostasis in human mesenchymal …

SIRT proteins, especially SIRT1, demonstrate protective roles against vascular aging. Here we will review multiple functions of SIRT proteins during vascular aging and the clinical capacity of …