2025年1月5日 · SIRT1 enhances Nrf2, activates HO-1, protects against oxidative injury, and decreases neuronal death. This has been associated with numerous neurodegenerative and …

2016年11月17日 · Collectively, our findings, for the first time, elucidate a precise mechanism for attenuation of HgCl 2 -induced liver dysfunction by dietary luteolin via regulating …

By applying western blot, it was found that hr5F alleviates the high glucose-induced superoxide overproduction insults by regulating SIRT1-PGC-1α/Nrf2 pathway, together with regulating …

Our recent study found that Sirt1 is hardly expressed and that a higher expression of Sirt1 protects brain tissues after SAHs by alleviating ferroptosis, which provides evidence for its...

SIRT1 can inhibit the release of proinflammatory factors and alleviate the oxidative damage of hepatocytes by activating Nrf2/HO-1 signaling pathway, thus playing a protective role against …

2025年1月5日 · Multiple studies have demonstrated that SIRT1 and Nrf2 share an important connection. SIRT1 enhances Nrf2, activates HO-1, protects against oxidative injury, and …

2018年4月1日 · By applying western blot, it was found that hr5F alleviates the high glucose-induced superoxide overproduction insults by regulating SIRT1-PGC-1α/Nrf2 pathway, …

2023年7月1日 · The increased expression of SIRT1 or SIRT 1 facilitated deacetylation process inhibits the function of different tumor suppressors including hypermethylated in cancer 1 …

NRF-1 is a downstream effector of SIRT1/PGC-1α and activates the expression of OxPhos components, mitochondrial transporters, and ribosomal proteins. Additionally, NRF-1 regulates …

目的:探究沉默信息调节因子1 （silent information regulator of transcription 1, SIRT1）在大鼠心肌缺血/再灌注损伤（myocardial ischemia/reperfusion injury, MI/RI）中对核因子E2相关因子2 …