NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [5] [6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.

SIRT3基因研究概况. SIRT3是哺乳动物 sirtuin蛋白家族 的成员，表现出 NAD+ 依赖性脱乙酰酶活性。人类sirtuins具有一系列分子功能，并已成为衰老，抗逆性和代谢调节中的重要蛋白质。

2024年12月25日 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and …

SIRT3 is a NAD +-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses to stress, including metabolic reprogramming and enhancing antioxidant defense mechanisms.

2019年7月11日 · Sirt3是线粒体中的一个重要的去乙酰化修饰酶，能够调控线粒体中许多代谢酶的活性，进而调控细胞线粒体的代谢。 经过多年的研究，发现Sirt3的活化与抗衰老、抗肿瘤...

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. Hitherto, SIRT3 has been ...

sirt3可通过各种通路及调节因子，对心肌纤维化、心肌肥厚、心肌凋亡等病理过程进行调节，对心力衰 竭的发生、发展产生重要影响。 本文主要综述 SIRT3 在心力衰竭各病理过程中的研究进展。

2025年2月1日 · SIRT3 regulates glucose uptake in cardiomyocytes and improves cardiac function in heart failure caused be blood pressure overload (Zeng et al., 2020). SIRT3 also has a key role in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, and electron transport chain (ETC) activation (Tanno et al., 2012).

2 天之前 · SIRT3 directly deacetylated PINK1 to promote mitophagy and cartilage anabolism. Specifically, PINK1 phosphorylated PKM2 at the Ser127 site, preserving its active tetrameric form. This inhibited ...

2012年5月15日 · SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic acid cycle, fatty acid β-oxidation and …