Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. [5][6] SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT4 exhibits NAD+-dependent deacetylase activity.

2024年12月25日 · SIRT4 (Sirtuin 4) is a Protein Coding gene. Diseases associated with SIRT4 include Renu Syndrome and Hyperinsulinemic Hypoglycemia, Familial, 6. Among its related pathways are Regulation of pyruvate metabolism and NAD metabolism.

2023年8月2日 · Sirtuins是广泛分布于细胞中的一种去乙酰化酶类，简单来说，就是 由一群蛋白质组成的长寿蛋白大家族，共有7个亚型SIRT1~SIRT7。 Sirtuins蛋白在细胞抗逆性、能量代谢、细胞凋亡和衰老过程中具有重要作用，故被称为长寿蛋白【1】。 SIRT家族成员在组织和细胞上具有不同的定位。 SIRT1和SIRT2主要在细胞核和细胞质中表达；SIRT3、SIRT4、SIRT5则主要定位于线粒体；SIRT6、SIRT7则位于细胞核内。 Sirtuins的功能. Sirtuins丰富的定位，也意味着SIRT …

2023年4月17日 · Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal...

2020年4月14日 · For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner.

2020年4月15日 · For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner.

2014年12月18日 · The major catalytic activity of the mitochondrial sirtuin, SIRT4, is as a lipoamidase rather than a deacetylase. SIRT4 hydrolyzes lipoamide modifications on the pyruvate dehydrogenase complex, inhibiting its activity and revealing an …

2025年2月8日 · SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3beta/CyclinD1 pathway. Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells. SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells.

2019年8月8日 · SIRT4 has been explored as a biomarker for coronary artery disease (CAD) due to its association with increased mitochondrial ROS (Singh et al., 2017). Moreover, SIRT4 has a tumour-suppressive activity by inhibiting mitochondrial glutamine metabolism (Jeong et al., 2013).

SIRT4 has been shown to play a crucial role in insulin secretion, fatty acid oxidation, amino acid metabolism, ATP homeostasis, apoptosis, neurodegeneration, and cardiovascular diseases. In addition, recent studies have demonstrated that SIRT4 acts as a tumor suppressor.