2020年4月6日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. Upon DNA damage, SIRT6 rapidly translocates to DNA damage sites, where it …

Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. Upon DNA damage, SIRT6 rapidly translocates to DNA damage sites, where it interacts with and recruits CHD4.

2024年9月27日 · 通过系统的构效关系研究和活性评价，最终获得了高降解活性的SIRT6小分子降解剂SZU-B6。该降解剂能够高效地降解肝癌细胞SK-HEP-1、Huh-7等肝癌细胞中的SIRT6蛋白(DC 50 < 200 nM; D max > 90%)，并与放化疗(IR和Sorafenib)结合显著抑制癌细胞增殖。机制研究表明，该降解剂可 ...

Here we report that the histone deacetylase SIRT6 coordinates with the chro-matin remodeler CHD4 to promote chromatin relax-ation in response to DNA damage. Upon DNA dam-age, SIRT6 rapidly translocates to DNA damage sites, where it interacts with and recruits CHD4.

2022年11月3日 · In this study, we found that ACSL5 is deacetylated by cytoplasmic SIRT6 and that it mitigates hepatic steatosis in a HFD-induced NAFLD model. Mechanistically, we show that SIRT6 binds to PA for translocation to the cytoplasm, …

2020年10月16日 · We show that SIRT6 associates with nucleosomes through two asymmetric binding sites using multiple contact points, including an intrinsically disordered C-terminus that associates with...

2021年7月17日 · Recently an interaction between SIRT6 and a subunit of NuRD, chromodomain helicase DNA-binding protein 4 (CHD4), has been shown in response to DNA damage, leading to displacement of heterochromatin protein (HP) 1 by CHD4 and promoting chromatin relaxation for HR-mediated repair .

2020年1月23日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. Upon DNA damage, SIRT6 rapidly...

sirt6可与chd4 相互作用，sirt6将chd4 募集 至DSBs 位点位点，SIRT6的C 末端域与CHD4 结 合，同时促进H3K9 脱乙酰基作用，这两点共同调

2022年12月1日 · In this study, we found that SIRT6 overexpression increased p-ATM via CHD4 during VSMC calcification. Collectively, SIRT6 deficiency in VSMCs leads to aggravation of vascular calcification by exacerbating DNA damage, and SIRT6 activation alleviates DNA damage and HVSMC calcification via upregulating p-ATM.