SIRT6 Is Essential for Adipocyte Differentiation by Regulating …
Using an adipogenesis assay, we demonstrate that SIRT6 deficiency impairs adipogenesis and that SIRT6 is an essential factor for mitotic clonal expansion during adipogenesis by inhibiting …
CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the ... - PubMed
This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the …
CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in
2016年12月1日 · Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 …
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of ...
2020年12月7日 · Sirt6 also regulates adipogenesis and thermogenesis, it is an essential factor in adipogenesis, by enhancing casein kinase 2 (CK2) activity (Chen et al., 2017; Kuang et al., …
Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma ...
The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase overexpressed in various human carcinomas and its high expression often …
Chen et al. demonstrate that SIRT6 is essential for adipogenesis by regulating mitotic clonal expansion. KIF5C is negatively regulated by SIRT6, and KIF5C is a negative regulator for …
SIRT6 通过调节有丝分裂克隆扩增对脂肪细胞分化至关重要。,Cell …
2017年3月28日 · SIRT6 是烟酰胺腺嘌呤二核苷酸 (NAD)+ 依赖性蛋白脱乙酰酶的进化上保守的沉默调节蛋白家族的成员。 在这里，我们表明前脂肪细胞中的 SIRT6 缺乏会阻止它们的脂肪生 …
SIRT6, a Mammalian Deacylase with Multitasking Abilities
As a negative regulator of mitotic clonal expansion, KIF5C interacts with CK2a, a catalytic subunit of CK2, and blocks CK2 kinase activity . In this context, SIRT6 has been shown to negatively …
SIRT6 Is Essential for Adipocyte Differentiation by Regulating …
2017年3月28日 · Using an adipogenesis assay, we demonstrate that SIRT6 deficiency impairs adipogenesis and that SIRT6 is an essential factor for mitotic clonal expansion during …
CK2α/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6 …
2021年7月13日 · Higher expression of CSNK2A1 and phosphorylated SIRT6 was associated with shorter survival in osteosarcoma patients. U2OS and KHOS/NP osteosarcoma cells with …