Is SIRT6 Activity Neuroprotective and How Does It Differ from …
2017年6月8日 · With regards to more acute neuronal injuries, evidence for a direct protective effect of SIRT6 on CNS neurons is lacking. On the other hand, a more definitive role for SIRT1 …
SIRT6 Through the Brain Evolution, Development, and Aging
2021年10月13日 · During development, Sirt6 represses the expression of pluripotent transcription factors Oct4, Sox2, and Nanog in ESCs differentiation, and Sirt6 deficiency increases the …
SIRT6 modulates lesion microenvironment in LPC induced …
2024年9月28日 · Sirtuin6 (SIRT6), a histone/protein deacetylase is of interest for its promising effect in transcriptional regulation, cell cycling, inflammation, metabolism and longevity. Here …
Sirtuins functions in central nervous system cells under …
SIRT6 is a chromatin-associated protein that stabilizes genomes and prevents cell premature senescence. In mice cortical and hippocampal primary neurons, SIRT6 is closely related with …
Sirt6 regulates the proliferation of neural precursor cells and ...
2024年2月16日 · Sirt6 deficiency is lethal, and newborn SIRT6-null cynomolgus monkeys show unfinished brain development. After the generation of a cortex-specific Sirt6 conditional …
SIRT6 prevent chronic cerebral hypoperfusion induced cognitive ...
2024年8月25日 · SIRT6 has emerged as an intriguing target for various conditions, including CNS disorders, cancer, aging and metabolic disorders. For instance, SIRT6 has been implicated in …
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global …
SIRT6 modulates lesion microenvironment in LPC induced
2024年9月28日 · Sirtuin6 (SIRT6), a histone/protein deacetylase is of interest for its promising effect in transcriptional regulation, cell cycling, inflammation, metabolism and longevity. Here …
SIRT6 Through the Brain Evolution, Development, and Aging
2021年10月12日 · Sirt6 is a mammalian Sirtuin notably related to aging and lifespan (Sirt6 targets and its mechanisms associated with aging are summarized in Table 1) (Vitiello et al., 2017). It …
The deacetylase SIRT6 reduces amyloid pathology and supports …
2024年12月10日 · Systemic pharmacological activation of SIRT6 ameliorated both amyloid pathology and cognitive deficits in APP/PS1 mice, a mouse model of AD. The findings …