2017年6月8日 · With regards to more acute neuronal injuries, evidence for a direct protective effect of SIRT6 on CNS neurons is lacking. On the other hand, a more definitive role for SIRT1 in protection against brain ischemic injury has been demonstrated, with a significantly increased in infarct volume in SIRT1 −/− mice compared to control (Hernández ...

2021年10月13日 · During development, Sirt6 represses the expression of pluripotent transcription factors Oct4, Sox2, and Nanog in ESCs differentiation, and Sirt6 deficiency increases the efficiency of somatic cell reprogramming, suggesting Sirt6 is a regulator of pluripotency.

2024年9月28日 · Sirtuin6 (SIRT6), a histone/protein deacetylase is of interest for its promising effect in transcriptional regulation, cell cycling, inflammation, metabolism and longevity. Here we show that SIRT6 participates in the remyelination process in …

SIRT6 is a chromatin-associated protein that stabilizes genomes and prevents cell premature senescence. In mice cortical and hippocampal primary neurons, SIRT6 is closely related with synaptic function, neuronal maturation and neuronal survival (Cardinale et al., 2015).

2024年2月16日 · Sirt6 deficiency is lethal, and newborn SIRT6-null cynomolgus monkeys show unfinished brain development. After the generation of a cortex-specific Sirt6 conditional knockout mouse model, we investigated the specific deletion of Sirt6 in NPCs at E10.5.

2024年8月25日 · SIRT6 has emerged as an intriguing target for various conditions, including CNS disorders, cancer, aging and metabolic disorders. For instance, SIRT6 has been implicated in the modulation of adult hippocampal neurogenesis, thus holding potential therapeutic implications for cognitive deficits-related diseases [ 39 , 40 ].

2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global downregulation of...

2024年9月28日 · Sirtuin6 (SIRT6), a histone/protein deacetylase is of interest for its promising effect in transcriptional regulation, cell cycling, inflammation, metabolism and longevity. Here we show that SIRT6 participates in the remyelination process in …

2021年10月12日 · Sirt6 is a mammalian Sirtuin notably related to aging and lifespan (Sirt6 targets and its mechanisms associated with aging are summarized in Table 1) (Vitiello et al., 2017). It is mainly nuclear and has different enzymatic activities, like ADP-ribosyl transferase, protein deacetylation, protein long-fatty acid deacylation, and DNA binding ...

2024年12月10日 · Systemic pharmacological activation of SIRT6 ameliorated both amyloid pathology and cognitive deficits in APP/PS1 mice, a mouse model of AD. The findings demonstrate that the activity of SIRT6 destabilizes APP and suggest that activating SIRT6 has therapeutic potential to reduce amyloid-associated pathology in patients with AD.