SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB ... - PubMed
2009年1月9日 · SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, …
清华大学药学院王钊课题组报道“SIRT6通过代谢重构缓解蒽环类药 …
SIRT6（Sirtuin 6）是一种NAD+依赖的去乙酰化酶，其被证实可对组蛋白H3K9、H3K18和H3K56进行去乙酰化修饰，进而在细胞代谢、DNA损伤修复、炎症反应以及肿瘤发生发展等多 …
SIRT6 is a histone H3 lysine 9 deacetylase that modulates ... - Nature
2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates …
The histone deacetylase Sirt6 regulates glucose homeostasis …
2010年1月22日 · Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a …
SIRT6 is a histone H3 lysine 9 deacetylase that modulates
2008年3月27日 · Here we show that the human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically …
SIRT6 将组蛋白 H3 赖氨酸 9 去乙酰化与 NF-κB 依赖性基因表达和 …
We propose that SIRT6 attenuates NF-kappaB signaling via H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling may contribute to premature and normal aging. NAD 依 …
SIRT6 regulates TNF-α secretion through hydrolysis of long
2013年4月3日 · To discover possible novel activity of SIRT6, we synthesized H3K9 peptides with different acyl groups (acetyl, malonyl, succinyl, butyryl, myristoyl and palmitoyl) and assayed …
Article SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB ...
2009年1月9日 · SIRT6 interacts with the NF-κB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-κB target gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 …
SIRT6, a Mammalian Deacylase with Multitasking Abilities
Early studies identified glycolytic genes as direct targets of SIRT6, in which SIRT6 deacetylated H3K9, repressing these genes and influencing glucose metabolism. At the promoters of key …
Myeloid sirtuin 6 deficiency causes obesity in mice by inducing ...
5 天之前 · Myeloid-specific SIRT6 deficiency promoted H3K9 acetylation in the promoter regions and the expression of genes encoding the norepinephrine-degrading enzyme MAOA and the …