Modulation of SIRT6 related signaling pathways of p-AKT/mTOR …
2024年12月5日 · MEMA enhanced hepatic SIRT6 and downregulated p-AKT/mTOR signaling, that subsequently reduced expressions of the lipid synthesis biomarkers (SREBP1c, SCD), …
SIRT和AMPK靶点通路知识讲解 - 知乎 - 知乎专栏
sirt1、sirt3、sirt6通过对ampk的促进与激活，抑制细胞氧化应激，减少ros和脂质过氧化； sirt1、sirt2、sirt6可以激活nrf2，调节抗氧化基因表达，从而对抗氧化应激损伤； sirt3激活foxo3基因 …
SIRT6 transcriptionally regulates global protein synthesis …
Here, we report that SIRT6, a nuclear-localized histone deacetylase represses global protein synthesis by transcriptionally regulating mTOR signalling via the transcription factor Sp1, …
Modulation of SIRT6 Related Signaling Pathways of p-AKT/mTOR …
2024年10月24日 · MEMA enhanced hepatic SIRT6 and downregulated p-AKT/mTOR signaling, that subsequently reduced expressions of the lipid synthesis biomarkers (SREBP1c, CPT1), …
SIRT6 regulates SREBP1c-induced glucolipid metabolism in …
2021年12月18日 · Recombinant SIRT6 alleviated the decrease in AMPKα and increase in mTORC1 (complex of mTOR, Raptor, and Rheb) caused by overnutrition. SIRT6 siRNA …
SIRT6 通过 AMPKα-mTORC1 通路调节 SREBP1c 诱导的肝脏和胰 …
重组 SIRT6 减轻了由营养过剩引起的 AMPKα 减少和 mTORC1（mTOR、Raptor 和 Rheb 的复合物）的增加。 SIRT6 siRNA 可逆转由 AMPK 激动剂和 mTOR 抑制剂引起的糖脂代谢紊乱， …
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance ... - PubMed
In vivo experiments showed that overexpression of SIRT6 promoted the inhibitory effect of radiation on the growth of NSCLC xenograft tumors in nude mice. SIRT6 can promote the …
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance
2021年5月25日 · SIRT6 can promote the radiosensitivity of NSCLC and inhibit the development of tumor by down-regulating the activity of PI3K/Akt/mTOR signaling pathway.
非经典 mTORC2 信号传导通过 SIRT6-FoxO1 调节棕色脂肪细胞脂 …
We provide evidence that SIRT6 is the FoxO1 deacetylase suppressed by mTORC2 and show an endogenous interaction between SIRT6 and mTORC2 in both mouse and human cells. Our …
【81600048】Sirt6通过调节自噬形成参与肺纤维化发病的机制研 …
雷帕霉素靶蛋白(mTOR)信号通路、自噬(Autophagy)以及沉默信息调节蛋白6 (Sirt6)被认为可能参与了纤维化过程的发生，但其中的机理还不明确。 我们已发表的研究表明IPF患者肺内存 …