The relapsing-remitting EAE model in SJL mice is the mouse model which most closely resembles human MS. The model is induced by immunization with [Ser 140]-PLP 139-151 in CFA emulsion, which may be followed by administration of pertussis toxin (PTX) in PBS if desired to increase severity of the first wave of EAE.

实验性自身免疫性脑脊髓炎（Experimental Autoimmune Encephalomyelitis，EAE）是最常用的实验性动物模型用来研究人炎症脱髓鞘病，多发性硬化病（Multiple sclerosis，MS）。 EAE是一系列免疫病理和神经病理机制交叉作用引发的综合性状况，导致机体出现近似MS的关键性病特征：炎症反应，脱髓鞘，轴突丧失和胶质增生。 就减少炎症的反调控机理和髓鞘再生也发生EAE模型中，因此，该模型也可用来研究这些过程。 另外，EAE通常用作细胞介导的器官特异性的自身 …

In this chapter, we detail the materials and methods used to induce active and adoptive EAE. We focus on disease induction in the SJL/J, C57BL/6, and BALB/c mouse strains, using peptides derived from proteolipid protein, myelin basic protein, and myelin oligodendrocyte glycoprotein.

This article details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein …

Click here for an overview of EAE and a list of models offered. Relapsing-remitting MS is the most common form of multiple sclerosis (MS) in human patients. This form of disease is most closely modeled by EAE induced by [Ser 140]-PLP 139-151 /CFA in SJL mice, making it the best model for study of compound effects on EAE relapses.

2011年2月17日 · Experimental autoimmune encephalomyelitis (EAE), a common animal model for MS, can be induced by immunization with myelin-derived antigens in adjuvants 1, 2,...

2023年4月23日 · The adoptive transfer EAE model in SJL mice is recommended for study of compound effects on the effector phase of EAE, independent of the immunization process. Immunization occurs only in donor mice.

1992年6月1日 · Here we describe conditions by which a relapsing-remitting form of EAE can be reliably induced by SJL/J mice either actively immunized with the major encephalitogenic PLP peptide, PLP 139–151 (S), or following adoptive transfer of PLP 139–151 (S) -specific T cells.

2015年8月31日 · 实验性自身免疫性脑脊髓炎 (experimental autoimmune encephalomyelitis, EAE)是一种以特异性致敏的CD4 + T细胞介导为主, 对实验动物进行髓鞘蛋白免疫构建的疾病模型。EAE与人类MS在临床、生化、免疫及病理等诸多方面具有相同的特征, 所以它是目前国际公认的 MS理想动物模型。

2009年6月8日 · Backcrossed to the SJL/J background, most RR mice spontaneously develop RR experimental autoimmune encephalomyelitis (EAE) with episodes often altering between different central nervous system tissues like the cerebellum, optic nerve, and spinal cord.