Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in …

The iC3b:C3 ratio correlated with the extent of SLE disease activity and with clinically meaningful changes in disease activity in patients with SLE. The iC3b:C3 ratio outperformed C3 and C4 …

2022年4月24日 · 补体 c3 和 c4 是补体系统的重要生物活性蛋白，主要由肝细胞和巨噬细胞合成，通过活化和裂解参与补体经典激活途和旁路激活途径，从而介导补体级联反应，是体内重要 …

Low serum levels of C3 or C4 are considered immunological biomarkers in the SLICC-2012 SLE classification criteria. As one of the immunological criteria, low levels of both C3 and C4 are …

In 2009, hypocomplementemia involving C3, C4, and total hemolytic complement (CH50) was proposed as an immunologic criterion to enhance the sensitivity of systemic lupus …

2021年2月10日 · We will review the use of traditional complement proteins, C3 and C4, and compare them to complement activation (split) products in plasma and on cell surfaces in …

此次研究结果说明，活动期SLE患者血清补体水平较健康体检者明显下降，其原因考虑与补体系统活化所致补体消耗有关，而活化的C3、C4参与的炎症反应，可诱发自身抗体与自身抗原形成 …

2019年1月1日 · Cell-bound CAPs (CB-CAPs) are complement split products bound to blood cells and were developed based on the rationale that activation products derived from C3 and C4 …

2021年2月10日 · Complement split products, C3dg, iC3b, and C4d, are elevated in SLE, and C3dg/C3 and iC3b/C3 ratios correlate with active SLE. C4d also is higher in patients with …

Complement activation is a key event in the pathogenesis of tissue inflammation and injury in systemic lupus erythematosus (SLE). This review is aimed at comparing the usefulness of …