
Sphingosine 1-phosphate receptor-targeted therapeutics in
2022年5月4日 · Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte...
Role of sphingosine-1-phosphate mediated signalling in systemic …
2021年10月1日 · Sphingosine-1-phosphate (S1P) is a bioactive lipid derived from sphingolipid metabolism and fulfills its biological function by coupling with its five receptors. In SLE, S1P …
Sphingosine -1 Phosphate Receptor-1 signaling maintains …
2024年11月9日 · The bioactive lipid sphingosine-1-phosphate (S1P), acting via S1P receptor 1 (S1P 1), is a key regulator of endothelial cell (EC) barrier function. We hypothesized that …
Sphingosine 1-phosphate receptor-targeted therapeutics in …
Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P-S1PR …
Pharmacodynamics of the S1P1 receptor modulator cenerimod in …
2024年11月22日 · Sphingosine-1-phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective …
Sphingosine 1-phosphate receptor-targeted therapeutics in …
Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P–S1PR …
狼疮性肾炎中 S1P/S1PR1 轴通过 NLRP3 炎性体激活促进巨噬细胞 …
狼疮性肾炎(LN)是系统性红斑狼疮(SLE)的常见并发症,也是 患者死亡的主要原因。 先前的研究表明,SLE 患者和小鼠狼疮模型的血浆样本中 S1P 水平升高。 FTY720 ,靶向S1P受 …
Pharmacodynamics of the S1P - PubMed
Sphingosine-1-phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective S1P 1 receptor …
Role of sphingosine-1-phosphate mediated signalling in
Sphingosine-1-phosphate (S1P) is a central bioactive lipid of sphingolipid metabolism, which serves a pivotal role in regulating numerous physiological and pathological processes. As a …
2024年11月22日 · Sphingosine- 1- phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective …