2024年12月25日 · SMARCB1 (SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1) is a Protein Coding gene. Diseases associated with SMARCB1 include Coffin-Siris …

SWI/SNF -related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. [5][6][7] The protein encoded …

Loss of SMARCB1 has been implicated in the initiation of cancers such as malignant rhabdoid tumor (MRT), atypical teratoid rhabdoid tumor (ATRT), and, more recently, renal medullary …

2024年3月27日 · We report that the little-studied gene DDB1–CUL4-associated factor 5 (DCAF5) is required for the survival of SMARCB1 -mutant cancers. We show that DCAF5 has a quality …

2023年11月10日 · smarcb1 del表明smarcb1基因缺失，导致swi/snf亚基水平降低，亚基融入染色质复合物减少(pmid: 27941797)，以及细胞培养中egfr和met通路信号的过度激活(pmid: …

2022年7月27日 · SMARCB1 is a critical component of the BAF complex that is responsible for global chromatin remodeling. Loss of SMARCB1 has been implicated in the initiation of …

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury. SMARCB1 loss interacts with neuronal differentiation …

The SMARCB1 gene provides instructions for making a protein that forms one piece (subunit) of several different protein groupings called SWI/SNF protein complexes. Learn about this gene …

SMARCB1 (also known as SNF5, INI1, and BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in nearly all pediatric rhabdoid tumors. These …

In this review, we give a general overview of SMARCB1, its role in various cancers including germline mutations, association with genetic syndromes and role in future targeted therapies. …