2018年3月20日 · The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve.

We describe detailed surgical procedures to establish the SNI mouse model that has been widely used for investigating mechanisms of neuropathic pain. Keywords: Mouse pain model, SNI surgery, Peripheral nerve injury, Sciatic nerve, Neuropathic pain

保留神经损伤(sni)模型诱发神经性疼痛的症状，如 机械性异位痛 ，即由触觉刺激引起的疼痛，通常不会引起疼痛反应。 sni小鼠模型包括结扎坐骨神经三个分支中的两个（胫神经和腓总神经），而腓肠神经保持完整的。

2011年8月18日 · The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful response [1]. The SNI mouse model involves ligation of two of the three branches of the sciatic nerve (the tibial nerve and the common peroneal nerve), while the sural ...

2003年10月1日 · Sparing the tibial branch of the sciatic nerve (ie, cutting the common peroneal and sural branches) produced the greatest and most reproducible reduction in nociceptive threshold. We find the SNI model in the mouse to be highly reproducible with respect to both behavioral and anatomic changes.

2023年2月8日 · We show synchronized activation of DRG neurons occurs rapidly in a spared nerve injury (SNI) mouse model of pain. Importantly, the synchrony, not the level, of DRG neuronal activity after SNI...

2025年3月11日 · This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes.

2011年8月18日 · The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact.

In the spared nerve injury (SNI) model in rats, the common peroneal and tibial nerves are injured, producing consistent and reproducible pain hypersensitivity in the territory of the spared sural nerve. In this study, we investigated whether SNI in mice is also a valid model system for neuropathic pain.

2011年8月18日 · 周围神经性疼痛是一种严重的慢性疼痛病症，可能由周围神经系统中感觉神经的创伤引起。 备用神经损伤 (SNI) 模型会诱发神经性疼痛的症状，例如机械性异常性疼痛，即通常不会引起疼痛反应的触觉刺激引起的疼痛 [1]。 SNI 小鼠模型包括结扎坐骨神经三个分支中的两个分支（胫神经和腓总神经），而腓肠神经则保持完整 [2]。 病变导致爪外侧区域出现明显的超敏反应，该区域由幸存的腓肠神经支配。 鼠标的非操作侧可以用作控件。 SNI 模型的优点是反应的 …