SOCS2 Gene - GeneCards | SOCS2 Protein | SOCS2 Antibody
2024年12月25日 · SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Hematologic Cancer and Polycythemia Vera. …
SOCS Regulation of the JAK/STAT Signalling Pathway - PMC
SOCS2-deficient mice grow to gigantic proportions and display reduced neuronal density and aberrant neuronal differentiation due to perturbations in growth hormone signalling [30-32]. …
Expression Characteristics, Immune Signature, and Prognostic …
2024年9月22日 · SOCS family genes are mainly related to the PIK3R3, GHR, and TNS4 pathways. Additionally, this study revealed that STAT3, PPAR-gamma 2, and IRF-2 are …
SOCS Proteins in Macrophage Polarization and Function - PMC
Recent studies have established strong potential for suppressor of cytokine signaling (SOCS) proteins to regulate M1 and M2 macrophage polarization (4 – 7). Here, the focus will be on the …
Targeting SOCS2 alleviates myocardial fibrosis by reducing nuclear ...
2024年10月1日 · SOCS2 promotes myocardial fibrosis progression through Wnt/β-catenin pathway. SOCS2 is transcriptionally activated by Wnt/β-catenin pathway. Knocking down …
细胞因子信号传导抑制因子 2（SOCS2）基因 | MCE
SOCS 家族成员是细胞因子可诱导的细胞因子受体负调节因子，通过 Janus 激酶/信号转导和转录通路 (JAK / STAT 通路) 的激活进行细胞因子受体信号传导。 SOCS 家族蛋白与信号复合物的 …
邵春林教授团队研究发现：SOCS2通过诱导SLC7A11泛素化与降解 …
2022年8月23日 · 分子机制 研究表明，SOCS2作为一种E3泛素连接酶，可特异性地诱导SLC7A11蛋白的泛素化与降解，从而促进HCC的辐射增敏。 HCC细胞受辐照后，SOCS2表 …
SOCS2: physiological and pathological functions - PubMed
2016年1月1日 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal …
多组学整合分析肝癌 SOCS 家族的表达特征、免疫特征和预后价 …
2024年9月23日 · 此外，这项研究表明 STAT3、PPAR-gamma 2 和 IRF-2 是调节 SOCS 家族成员的重要转录因子。 SOCS家族成员的表达水平与肝癌中的免疫浸润密切相关。 研究还表明
Suppressor of cytokine signaling (SOCS) 2, a protein with multiple ...
2006年12月1日 · SOCS2 overexpression in vitro shows a partial inhibition of GH-dependent signaling (e.g. phosphorylation of STAT5 and JAK2, DNA-binding capacity of STAT5 and GH …