Sox9, also known as SRY-Box Transcription Factor 9, is an important gene is sex determination. The SOX family of genes are all transcription factors for the Y chromosomal sex-determining factor SRY. The SRY gene encodes the SOX transcription factor while it upregulates Sox9.

The SOX9 gene provides instructions for making a protein that plays a critical role during embryonic development. The SOX9 protein is especially important for development of the skeleton and plays a key role in the determination of sex before birth.

2024年12月25日 · SOX9 (SRY-Box Transcription Factor 9) is a Protein Coding gene. Diseases associated with SOX9 include Campomelic Dysplasia and 46,Xx Sex Reversal 2. Among its related pathways are Gene expression (Transcription) and Mammalian disorder of …

We show here that SOX9 is an astrocyte-specific nuclear marker in all major areas of the CNS outside of the neurogenic regions. Based on SOX9 immunolabeling, we document that astrocytes constitute a smaller fraction of total cell number than previously estimated in …

In this review, we confine our discussion to one of the well-characterized SoxE proteins, Sox9. After discussing multiple levels of regulation and mechanisms, we review the versatile functions of Sox9 in germ layers and adult tissues as a stem cell regulator.

2023年7月24日 · Here we tackle this question with SOX9, a master regulator that diverts embryonic epidermal stem cells (EpdSCs) into becoming hair follicle stem cells. By engineering mice to re-activate SOX9...

2025年3月8日 · Sox9 and Sex Determination: Plays a role in sex-specific gene expression in gonads. The SOX9 protein is a transcription factor that plays a crucial role in the development and function of the gonads, the reproductive organs. Its primary function is to regulate the expression of sex-specific genes, which are essential for the proper ...

The SOX9 transcription factor controls the differentiation of many cell types among vertebrates. The SOX9 gene locus is large and complex and contains various tissue-specific enhancers. Individual enhancers direct specific expression of SOX9 in chondrocytes, Sertoli cells and cranial neural crest ce …

2025年3月8日 · Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.

SOX9 belongs to the family of SRY-related high-mobility-group box (SOX) transcription factors that mediate cell fate by activating genes that maintain pluripotency, direct cell lineage differentiation, and sustain adult tissue homeostasis.