PI3K-Akt信号通路是细胞中一个关键的信号传导网络，它可被多种细胞刺激或毒性损伤所激活，并在调控转录、翻译、增殖、生长和存活等基本细胞功能中扮演重要角色。 当生长因子与细胞膜上的 受体酪氨酸激酶 （RTK）或 G蛋白偶联受体 （GPCR）结合时，它们会分别刺激Ia和Ib类PI3K同工酶。 这些被激活的PI3K在细胞膜上催化磷脂酰肌醇，产生第二信使分子—— 磷脂酰肌醇-3,4, 5-三磷酸酯 （PIP3）。 PIP3随后作为关键分子，帮助激活Akt（蛋白激酶B）。 一旦Akt被激活， …

本综述介绍了 Sp1 转录因子与 MAPK、p38、JAK/STAT 和 PI3K/Akt 信号通路在正常组织和各种病理（包括恶性疾病）中的活性之间关系的数据。 Sp1 是 Sp/KLF 家族的转录因子，可与基因调控区域中富含 GC 的基序结合。 Sp1参与细胞增殖、凋亡和分化以及血管生成的调节。 在肺癌、乳腺癌、胰腺癌、甲状腺癌、胃癌和神经胶质瘤等肿瘤疾病的细胞中发现了高水平的 SP1 表达，以及由于翻译后修饰而导致的异常转录活性。 先天性心脏病，以及神经退行性疾病，包括亨廷顿病 …

2015年12月21日 · Our results show that solamargine inhibits the growth of human lung cancer cells through inactivation of Akt signaling, followed by reduction of SP1 and p65 protein expression. This results in the inhibition of EP4 gene expression. The cross-talk between SP1 and p65, and the positive feedback regula …

2022年10月5日 · This review presents data on the involvement of Sp1 in the regulation of the expression of genes encoding components of the MAPK, p38, JAK/STAT, and PI3K/Akt signaling pathways, as well as how the activity of these signaling cascades is associated with the transcriptional activity of the Sp1 protein in human and animal cells in normal ...

2020年8月1日 · Inhibition of integrin αVβ5 remarkably reversed the expression of VEGFR2 and phosphorylation level of Akt in HUVECs grown on higher stiffness substrate. Except that, PI3K inhibitor also suppressed the phosphorylation level of Akt and the expressions of VEGFR2 and nuclear Sp1 evidently.

2022年8月1日 · pi3k-akt-mtor是经典的响应胰岛素信号的通路。 当进食后，被分解的葡萄糖进入血液促进胰岛素的释放，胰岛素作为响应营养富余的信号，会指导细胞进行吸收利用这些营养。

2015年12月21日 · The cross-talk between SP1 and p65, and the positive feedback regulatory loop of PI3-K/Akt signaling by EP4 contribute to the overall responses of solamargine in this process. This study unveils a novel mechanism by which solamargine inhibits growth of human lung cancer cells.

Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. A high level of SP1 expression, as well as its aberrant transcriptional activity d …

2020年8月1日 · Our results showed that PI3K inhibitor suppressed the expression nuclear Sp1 significantly, simultaneously attenuated the phosphorylation level of Akt and the expressions of VEGFR2. Taken all together, higher matrix stiffness upregulates VEGFR2 expression in HUVECs via activating αVβ5/Akt-Sp1 pathway.

转录因子SP1（Specificity Protein 1）与多条信号通路相关，主要包括以下几种： MAPK信号通路 ：SP1可以被MAPK家族的激酶（如ERK、JNK和p38）磷酸化，从而调节其转录活性。