SP7-associated signaling pathways, SP7-dependent target genes, and epigenetic regulations of SP7 serve as new therapeutic targets in the treatment of skeletal disorders. This review addresses the importance of SP7-regulated bone development in studying bone health and skeletal disease.

Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. [5] It is a member of the Sp family of zinc-finger transcription factors [ 5 ] It is highly conserved among bone-forming vertebrate species [ 6 ] [ 7 ] It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of ...

2023年3月7日 · Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone development regulated by SP7 is strongly associated with human bone health. Dysfunction of SP7 results in common or rare skeletal diseases, including osteoporosis and osteogenesis imperfecta with different inheritance patterns.

Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone development regulated by SP7 is strongly associated with human bone health. Dysfunction of SP7 results in common or rare skeletal diseases, including osteoporosis and osteogenesis imp …

sp7 在骨骼中的关键作用得到了其与人类骨骼疾病的相关性的支持。 本综述旨在概述 Sp7 在骨骼发育和维护中的作用，特别关注我们对 Sp7 在生理和病理条件下如何在骨骼中发挥作用的理解的最新进展。

2025年2月8日 · The identification and initial characterization of the SP7 gene will facilitate the study of the molecular regulation of osteoblast differentiation in humans. Sp7 expression in humans is largely confined to osteoblasts and chondrocytes, both of which differentiate from the mesenchymal lineage.

SP7-associated signaling pathways, SP7-dependent target genes, and epigenetic regulations of SP7 serve as new therapeutic targets in the treatment of skeletal disorders. This review addresses the importance of SP7-regulated bone development in studying bone health and skeletal disease.

2022年5月18日 · The critical role of SP7 in the skeleton is supported by its relevance to human skeletal diseases. This review aims to overview the Sp7 actions in skeletal development and maintenance, particularly focusing on recent advances in our understanding of how Sp7 functions in the skeleton under physiological and pathological conditions.

2021年11月3日 · 在《自然通讯》上发表的一项研究中，由马萨诸塞州总医院 (MGH)的研究人员领导的一个国际团队揭示了骨细胞是如何形成树突的——这一发现可能会导致维持这些突起的策略，从而帮助保护个人终生的骨骼健康。 在他们的研究中，研究人员发现，骨细胞中Sp7基因的缺失会导致骨细胞树突的严重缺陷。 Sp7基因与罕见和常见的骨骼疾病都有关联。 ?这个基因为一种叫做转录因子的蛋白质编码，它控制着其他基因的表达。 研究小组发现，Sp7转录因子以一种叫 …

Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation. [provided by RefSeq, Jul 2010]